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The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells

Related publications (48)

Mechanisms of Disease: cancer stem cells - targeting the evil twin

Classical antineoplastic treatments such as chemotherapy or radiation can efficiently eradicate the majority of proliferating and genetically unstable malignant cells within neoplastic lesions. There is increasing evidence, however, that these regimens fre ...

2008

Gold(III) compounds as anticancer agents: Relevance of gold-protein interactions for their mechanism of action

Paul Joseph Dyson, Christian Hartinger, Angela Casini

Gold(III) compds. constitute an emerging class of biol. active substances, of special interest as potential anticancer agents. During the past decade a no. of structurally diverse gold(III) complexes were reported to be acceptably stable under physiol.-lik ...

2008

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling

Melody Swartz, Alice Anna Tomei, Mark Fleury, Carolyn Yong Pullin

CCR7 is implicated in lymph node metastasis of cancer, but its role is obscure. We report a mechanism explaining how interstitial flow caused by lymphatic drainage directs tumor cell migration by autocrine CCR7 signaling. Under static conditions, lymphatic ...

Elsevier2007

Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

Paul Joseph Dyson, Zhaofu Fei, Xunhui Wang

The toxicity of ethyl-, butyl-, octyl-, benzyl-, and allyl-substituted 1-alkyl-3-methylimidazolium, alkylpyridinium, N-alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium (choline derivs.) and alkyl-triethylammonium salts towards HeLa cells has been studied. The ...

2007

In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes

Paul Joseph Dyson, Gabor Laurenczy, Claudine Scolaro, Gianni Sava

The antitumor activity of the organometallic ruthenium(II)-arene complexes, RuCl2(eta(6)-arene)(PTA), (arene = p-cymene, toluene, benzene, benzo-15-crown-5, 1-ethylbenzene-2,3-dimethylimidazolium tetrafluoroborate, ethyl benzoate, hexamethylbenzene; PTA = ...

2005

Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE

Friedrich Beermann

We have analysed the importance of fibroblast growth factor 2 (FGF2) in tumor development. In a transgenic mouse model (Tyrp1-Tag) tumors form in the retinal pigment epithelium (RPE), invade surrounding tissues, and metastasize to lymph node and spleen. To ...

2002

Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity

Melody Swartz

The goal of this study was to compare growth characteristics of cells shed from a tumour with the native tumour cells. The human colon adenocarcinoma LS174T and its highly metastatic subline LS LiM 6 were grown as tissue-isolated tumours in nude mice and p ...

1999

Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines

Steinunn Baekkeskov Hanahan

Culturing and comparing the discrete stages of tumorigenesis provide a route to defining important components of the cancer phenotype and, in addition, present the opportunity to establish cell cultures more representative of normal cells than the ultimate ...

American Society for Microbiology1993

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