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Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

Related publications (34)

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Projection Structure of the Secondary Citrate/Sodium Symporter CitS at 6 angstrom Resolution by Electron Crystallography

Henning Paul-Julius Stahlberg

CitS from Klebsiella pneumoniae acts as a secondary symporter of citrate and sodium ions across the inner membrane of the host. The protein is the best characterized member of the 2-hydroxycarboxylate transporter family, while no experimental structural in ...

Elsevier BV2012

Allenes in Molecular Materials

Pablo Rivera Fuentes

A review. This Minireview provides a crit. account of the development of allene-contg. advanced functional materials, starting with the design and synthesis of stable and enantiopure building blocks. A variety of systems, including shape-persistent macrocy ...

2012

Development of X-Ray Powder Diffraction Methods for Biomolecules

Sebastian Basso

The comparable order of magnitude between interatomic distances in a crystal and the wavelength of X-rays make X-ray crystallography the ideal analytical tool to gain insight into the structure of crystalline material, including biomolecules. Nevertheless, ...

EPFL2011

Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus

Matteo Dal Peraro

The M2 protein of influenza A virus performs the crucial function of transporting protons to the interior of virions enclosed in the endosome. Adamantane drugs, amantadine (AMN) and rimantidine (RMN), block the proton conduction in some strains, and have b ...

2011

Elucidating the Role of Quaternary Structure in Modulating Macrophage Migration Inhibitory Factor (MIF) Functions

Farah El Turk

Macrophage Migration Inhibitory Factor (MIF) is a multifunctional protein and a major mediator of innate immunity. The paramount importance of MIF in the pathogenesis of many inflammatory, infectious, auto-immune and oncogenic diseases led to its emergence ...

EPFL2010

Preparation of 2D Crystals of Membrane Proteins for High-Resolution Electron Crystallography Data Collection

Henning Paul-Julius Stahlberg, Radosav Svetozara Pantelic

Electron crystallography is a powerful technique for the structure determination of membrane proteins as well as soluble proteins. Sample preparation for 2D membrane protein crystals is a crucial step, as proteins have to be prepared for electron microscop ...

Elsevier2010

Electromechanics on the Nanometer Scale: Emerging Phenomena, Devices, and Applications

Nava Setter

Coupling between electrical and mechanical phenomena is ubiquitous in nature and underpins the functionality of materials and systems as diversified as ferroelectrics and multiferroics to electroactive molecules to biological systems. Recent years have wit ...

2009

Solute energy based REMD

Molecular dynamics (MD) simulations have increasingly contributed to the understanding of biomolecular processes, allowing for predictions of thermodynamic and structural properties. Unfortunately, the holy grail of protein structure prediction was soon fo ...

EPFL2008

Vibrational spectra of proteins and topologically disordered solids display a common anomaly at low frequencies, known as boson peak. We show that such feature in globular proteins can be deciphered in terms of an energy landscape picture, as it is for gla ...

American Physical Society2006

We present a review of wave packet dynamics in different systems and stress their relation to information on the ultrafast structural changes. We show how dynamical information is obtained from ultrafast optical pump-probe studies on structural changes in ...

SPRINGER2005