Publication
Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans
Related publications (34)
Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses
Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ phy ...
2021Enhancing T-cell response in cancer immunotherapy using nanoparticles
Immunotherapy has been used in oncology in order to awaken the immune system of the patient against cancer. Within this promising field is emerging the use of therapeutic cancer vaccines, using tumor specific antigens to stimulate dendritic cells (DCs) ex ...
EPFL2021How single-cell immunology is benefiting from microfluidic technologies
The immune system is a complex network of specialized cells that work in concert to protect against invading pathogens and tissue damage. Imbalances in this network often result in excessive or absent immune responses leading to allergies, autoimmune disea ...
2020HLA tapasin independence: broader peptide repertoire and HIV control
Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the absence of tapasin, an essential component of the peptide loading complex. We quantified tapasin dependence of all allotypes that are common in European and Af ...
NATL ACAD SCIENCES2020Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma
Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Elisa Oricchio, Jessica Sordet, Natalya Katanayeva, Julien Racle, Sarah Wehrle, Elena Battistello, Stephanie Jocelyne Sungalee, Elie Charles Eugène Dheilly, Giovanni Ciriello, Marco Mina
Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...
2020Evolution of longevity improves immunity in Drosophila
Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin ...
JOHN WILEY & SONS LTD2018Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity
Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...
EPFL2018New roles of the lymphatic endothelium in modulating adaptive immunity: implications for immune tolerance and cancer immunotherapy
Lambert Charles François Potin
Lymphatic vessels have traditionally been considered as passive conduits for interstitial fluid drainage and for immune cell trafficking to lymph nodes. In the last two decades, many studies have challenged this classical dogma: lymphatic endothelial cells ...
EPFL2018New immunomodulatory roles of lymphatic endothelium and implications for immunotherapy
The lymphatic system serves a critical role in fluid homeostasis, lipid metabolism and immune surveillance. The growing appreciation of its implication in various diseases challenges the conventional view of lymphatics as a passive transport system. Tradit ...
EPFL2016Bioengineering approaches in immunotherapy
Vaccination has been regarded to as the most attractive immunotherapy for cancer because of its ability to instruct immune cells to recognize and kill tumor cells. Exosomes are one of the most recent discoveries translated from basic biology into experimen ...
EPFL2016