Publications related to UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

Hilal Lashuel, Bruno Claude Daniel Fauvet, Loay Awad, Mirva Hejjaoui

It has been more than a century since the first evidence linking the process of amyloid formation to the pathogenesis of Alzheimer's disease. During the last three decades in particular, increasing evidence from various sources (pathology, genetics, cell c ...

Elsevier2012

Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis

Maurizio Molinari

Nascent polypeptides entering the endoplasmic reticulum (ER) are covalently modified with pre-assembled oligosaccharides. The terminal glucose and mannose residues are immediately removed after transfer of the oligosaccharide onto newly synthesized polypep ...

Elsevier Science London2012

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

Bernard Schneider, Ying Liu, Philippe Guillaume Coune

Accumulation of misfolded alpha-synuclein (alpha S) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other alpha-synucleinopathies. However, how alpha S causes neurodegeneration is unresolved. Because cellular accumulation of ...

Society for Neuroscience2012

Dynamics of Unfolded Protein Transport through an Aerolysin Pore

Françoise Gisou van der Goot Grunberg

Protein export is an essential mechanism in living cells and exported proteins are usually translocated through a protein-conducting channel in an unfolded state. Here we analyze, by electrical detection, the entry and transport of unfolded proteins, at th ...

2011

Cyclosporine A-Sensitive, Cyclophilin B-Dependent Endoplasmic Reticulum-Associated Degradation

Maurizio Molinari, Riccardo Bernasconi

Peptidyl-prolyl cis/trans isomerases (PPIs) catalyze cis/trans isomerization of peptide bonds preceding proline residues. The involvement of PPI family members in protein refolding has been established in test tube experiments. Surprisingly, however, no da ...

Public Library of Science2010

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

Giovanni Dietler, Paolo De Los Rios, Jérôme Flakowski, Raffaele Mezzenga

The aggregation of proteins is central to many aspects of daily life, including food processing, blood coagulation, eye cataract formation disease and prion-related neurodegenerative infections[1–5]. However, the physical mechanisms responsible for amyloid ...

Nature Publishing Group2010

N-glycan structures: recognition and processing in the ER

Maurizio Molinari, Riccardo Bernasconi

The processing of Winked glycans determines secretory protein homeostasis in the eukaryotic cell. Folding and degradation of glycoproteins in the endoplasmic reticulum (ER) are regulated by molecular chaperones and enzymes recruited by specific oligosaccha ...

2010

Toward Structural Dynamics: Protein Motions Viewed by Chemical Shift Modulations and Direct Detection of C ' N Multiple-Quantum Relaxation

Geoffrey Bodenhausen, Daniel Abergel

Multiple quantum relaxation in proteins reveals unexpected relationships between correlated or anti-correlated conformational backbone dynamics in alpha-helices or beta-sheets. The contributions of conformational exchange to the relaxation rates of C'N coh ...

American Chemical Society2010

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UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

Dynamics of Unfolded Protein Transport through an Aerolysin Pore

Cyclosporine A-Sensitive, Cyclophilin B-Dependent Endoplasmic Reticulum-Associated Degradation

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

N-glycan structures: recognition and processing in the ER

Toward Structural Dynamics: Protein Motions Viewed by Chemical Shift Modulations and Direct Detection of C ' N Multiple-Quantum Relaxation

Graph Chatbot

Chat with Graph Search

Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis

Cyclosporine A-Sensitive, Cyclophilin B-Dependent Endoplasmic Reticulum-Associated Degradation

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

N-glycan structures: recognition and processing in the ER

Toward Structural Dynamics: Protein Motions Viewed by Chemical Shift Modulations and Direct Detection of C ' N Multiple-Quantum Relaxation

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

Dynamics of Unfolded Protein Transport through an Aerolysin Pore

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity