Model Organisms Proteomics-From Holobionts to Human Nutrition
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We propose an experimental study where simplistic organ- isms rise from inanimate matter and evolve solely through physical interactions. These organisms are composed of three types of macroscopic building blocks floating in an agitated medium. The dynamis ...
Living organisms are endowed with three structural principles: multicellular architecture, cellular division, and cellular differentiation. Implemented in digital according to these principles, our bit slice processors present self-organizing mechanisms li ...
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Assigning functions to every gene in a living organism is the next challenge for functional genomics. In fact, 85-90% of the 19,000 genes of the nematode Caenorhabditis elegans genome do not produce any visible phenotype when inactivated, which hampers det ...
Alternative splicing is now recognized as a major mechanism for transcriptome and proteome diversity in higher eukaryotes, yet its evolution is poorly understood. Most studies focus on the evolution of exons and introns at the gene level, while only few co ...
This work investigates the influence of diffusion adaptation on the behavior of networks of micro-organisms that are subject to Brownian fluctuations in the motion of their constituent agents. The organisms are assumed to share information, usually through ...
Over the past five years there have been significant advances in both genetic and palaeoecological research on the ancestry of populations. The alternation of cold and warm stages during the Ice Ages has caused repeated geographic restriction and expansion ...
A general method for covalent labeling of fusion proteins in vivo that complements the existing methods for protein labeling in vivo and in vitro is presented. This new method might lead to new ways of studying and manipulating proteins in living cells. Co ...
Maintaining homeostasis in higher organisms involves a complex interplay of multiple ubiquitous and organ-specific molecular mechanisms that can be characterized using functional genomics technologies such as transcriptomics, proteomics, and metabonomics a ...
Nature is an incredibly complex system resulting from the interactions of many different interdependent species, composed of many individual organisms, which are in turn composed of an extremely large number of cells. In multi-cellular organisms, the paral ...
This article describes an implementation of a basic multiprocessor system that exhibits replication and differentiation abilities on the POEtic tissue, a programmable hardware designed for bio-inspired applications. As for a living organism, whose existenc ...
