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Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss

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Decorin

Decorin is a protein that in humans is encoded by the DCN gene. Decorin is a proteoglycan that is on average 90 - 140 kilodaltons (kDa) in molecular weight. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein.

Möbius function

The Möbius function μ(n) is a multiplicative function in number theory introduced by the German mathematician August Ferdinand Möbius (also transliterated Moebius) in 1832. It is ubiquitous in elementary and analytic number theory and most often appears as part of its namesake the Möbius inversion formula. Following work of Gian-Carlo Rota in the 1960s, generalizations of the Möbius function were introduced into combinatorics, and are similarly denoted μ(x). For any positive integer n, define μ(n) as the sum of the primitive nth roots of unity.

Testosterone (medication)

Testosterone (T) is a medication and naturally occurring steroid hormone. It is used to treat male hypogonadism, gender dysphoria, and certain types of breast cancer. It may also be used to increase athletic ability in the form of doping. It is unclear if the use of testosterone for low levels due to aging is beneficial or harmful. Testosterone can be used as a gel or patch that is applied to the skin, injection into a muscle, tablet that is placed in the cheek, or tablet that is taken by mouth.

Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. Relative to estradiol, both estrone and estriol have far weaker activity as estrogens.