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A general and practical N-iodosuccinimide (NIS)-promoted aza-Friedel–Crafts reaction of various aromatic nucleophiles with N-acylimines generated in situ from a-amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary.
Qian Wang, Jieping Zhu, Rémi Julien Sylvain Andres
Wendy Lee Queen, Jordi Espin Marti, Jocelyn Richard Roth, Till Marian Schertenleib, Nazanin Taheri, Ilia Kochetygov, Anita Justin, Sophia Alessandra Pache