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Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Related publications (38)
Characterization of the gut-bone marrow axis through bile acid signaling
Communication between the intestine and other organs such as the lungs, brain or bones is mediated by several metabolites, like short-chain fatty acids or bile acids, that relay information about nutritional and microbiota status. Bile acids are endogenous ...
EPFL2024Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease
Acute leukemia has a high mortality rate of approximately 50%, and current methods are not effective in predicting disease progression and relapse. To improve our understanding of hematopoiesis and develop new markers for predicting disease relapse in dead ...
EPFL2023New approaches to uncover the minimally functional hematopoietic niche using the adipocytic differentiation axis: pharmacological modulation and adrenal niche induction
Hematopoietic Stem and Progenitor Cells (HSPCs) reside in their niche, a structure that regulates the balance of cellular quiescence, self-renewal and commitment towards differentiated cells. This highly plastic niche is formed by several cellular players, ...
EPFL2022Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis
Josefine Catharina Pedersen Tratwal
Over the last decade, bone marrow (BM) adipose tissue (BMAT) has emerged as a distinct adipose depot with unique metabolic properties and effects both in homeostasis and in the progression of disease.
We provide a first comprehensive review of existing an ...
EPFL2020MarrowQuantAcross Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections
Olaia Maria Naveiras Torres-Quiroga, Olivier Burri, Rita Sarkis, Nicolas Kunz, Vasco Ledebur de Antas de Campos, Josefine Catharina Pedersen Tratwal, Frédérica Schyrr, Chiheb Boussema, Daniel Naveed Tavakol, Shanti Rojas-Sutterlin
The bone marrow (BM) exists heterogeneously as hematopoietic/red or adipocytic/yellow marrow depending on skeletal location, age, and physiological condition. Mouse models and patients undergoing radio/chemotherapy or suffering acute BM failure endure rapi ...
2020Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia
Filipe Amândio Brandão Sanches Vong Martins
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases, with a variable probability of transformation into acute leukemia, which is, in the vast majority of cases, of myeloid lineage. Nevertheless, rare cases of acute lymphoblastic leukemia ...
SPRINGER2020Metabolic and microenvironmental strategies to accelerate hematopoietic recovery post-aplasia
Vasco Ledebur de Antas de Campos
The procedure-associated mortality rate of bone marrow transplantations (BMT) remains close to 25%. The BMT is therefore only indicated for life-threatening diseases, with no replacement of this technology to be expected in the foreseeable future. Modest i ...
EPFL2019Modeling hematopoietic stem cell dynamics in bioengineered niches
Bone marrow transplantation is a well-established medical procedure for the treatment of various hematologic diseases. However, the relatively low number of hematopoietic stem cells (HSCs) that can be harvested, especially from umbilical cord blood, limits ...
EPFL2019The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo
Johan Auwerx, Lulu Liu, Wei Zhang, Yao Zhang, Na Zhang
Enhanced understanding of normal and malignant hematopoiesis pathways should facilitate the development of effective clinical treatment strategies for hematopoietic malignancies. Nuclear receptor corepressor 1 (NCoR1) has been implicated in transcriptional ...
AMER SOC HEMATOLOGY2019Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-alpha v (Itgav) regulates HSC proliferation. Systemic deletion of Postn resul ...
Nature Publishing Group2016