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Towards a new combination therapy for tuberculosis with next generation benzothiazinones

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Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Stewart Cole, Joao Pedro De Almeida Neres, Giulia Manina

Summary Tuberculosis is still a leading cause of death in developing countries, for which there is an urgent need for new pharmacological agents. The synthesis of the novel antimycobacterial drug class of benzothiazinones (BTZs) and the identification of t ...

2010

Crystal structure of the insect neuropeptide proctolin

Philip Pattison

The crystal structure of the neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr) is reported revealing the solid-state conformation of its molecules and their association in the crystal. ...

Royal Society of Chemistry2010

[(Methylcarbamothioyl)disulfanyl]methyl N-methylcarbamodithioate

Christine Neuhausen

The title compound, C5H10N2S5, was unintentionally obtained as the product of an attempted synthesis of a methyl-carbamodithioic acid using methylamine and carbon disulfide. In the molecule, two dithiocarbamate groups are bridged by a -CH2S- unit. The C-S- ...

2010

Paenibacillus barcinonensis is a soil bacterium bearing a complex set of enzymes for xylan degradation, including several secreted enzymes and Xyn10B, one of the few intracellular xylanases reported to date. The crystal structure of Xyn10B has been determi ...

2010

Crystal structure of [NBu4](2)[Pd-2{C-4(COOMe)(4)}(2)(mu-OH)(2)] determined ab initio by charge flipping

The crystal structure of bis(tetra-n-butylammonium)bis(mu(2)-hydroxo)-bis(1,2,3,4-tetrakis(methoxycarbonyl)-1,3-butadiene-1,4-diyl)-di-palladium, NBu4[Pd-2{C-4(COOMe)(4)}(2) (mu-OH)(2)], was determined ab initio by X-ray single-crystal diffractometry ...

2009

Hematite is a semiconducting mineral with a role in natural photoelectrochemical processes, and has been studied from the viewpoint of solar energy utilization. Hematite is an anisotropic conductor, with faster conduction parallel to (001) planes. Flatband ...

2009

, , ,

The previously proposed model postulating that the incommensurately modulated KNd(MoO

_4

)

_2

structure can act as a generator of the scheelite family members is validated here by refining the crystal structure of europium molybdate, Eu

_2

(MoO

_4

)

_3

. ...

2009

Comparative genomics with Staphylococcus aureus suggested the existence of a regulatory system governing beta-lactamase (BlaC) production in Mycobacterium tuberculosis. The crystal structure of Rv1846c, a winged helix regulator of previously unknown functi ...

2009

We present a complete characterization of the unit cell dynamics of a laser-excited tellurium crystal using femtosecond x-ray diffraction. The analysis offers a quantitative measure of the unit cell dynamics without making any assumptions on the symmetry o ...

American Physical Society2009

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

Stewart Cole, John McKinney, Neeraj Dhar, Claudia Sala, Giulia Manina, Elizabeth Fullam

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in ...

2009

, , ,

The previously proposed model postulating that the incommensurately modulated KNd(MoO

_4

)

_2

structure can act as a generator of the scheelite family members is validated here by refining the crystal structure of europium molybdate, Eu

_2

(MoO

_4

)

_3

. ...

2009