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Conditional Deletion of Ferritin H in Mice Reduces B and T Lymphocyte Populations
Related publications (77)
Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node
Lymphomas are a group of heterogeneous blood cancers that arise from lymphocytes. The two primary clinical classifications of lymphomas are Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). In particular, B-cell lymphoma refers to the malignancies ...
EPFL2023Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells
In lymphopenic environments, secondary lymphoid organs regulate the size of B and T cell compartments by supporting the homeostatic proliferation of mature lymphocytes. The molecular mechanisms underlying these responses and their functional consequences r ...
AMER SOC CLINICAL INVESTIGATION INC2022Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster
Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko, Alice Marra, Jasquelin Peña
Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions are poorl ...
NATL ACAD SCIENCES2020Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma
Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Elisa Oricchio, Jessica Sordet, Natalya Katanayeva, Julien Racle, Sarah Wehrle, Elena Battistello, Stephanie Jocelyne Sungalee, Elie Charles Eugène Dheilly, Giovanni Ciriello, Marco Mina
Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...
2020Durable and controlled depletion of neutrophils in mice
Etienne Meylan, Julien Robert Rémi Faget, Gael Luis Boivin, Caroline Anne-Lyse Contat, Jessica Christine Vazquez, Justine Pascual, Pierre-Benoit Bernard Ancey, Aspasia Gkasti
Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective ...
2020Factors influencing safety and efficacy of intravenous iron-carbohydrate nanomedicines: From production to clinical practice
Iron deficiency is an important subclinical disease affecting over one billion people worldwide. A growing body of clinical records supports the use of intravenous iron-carbohydrate complexes for patients where iron replenishment is necessary and oral iron ...
2020Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche
The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strategies for BM-rela ...
EPFL2019Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation
Berna Ayse Özkale Edelmann, Christina Myra Tringides
Mesenchymal stem cell (MSC) therapies demonstrate particular promise in ameliorating diseases of immune dysregulation but are hampered by short in vivo cell persistence and inconsistencies in phenotype. Here, we demonstrate that biomaterial encapsulation i ...
NATL ACAD SCIENCES2019Development of a nano-adjuvant cancer vaccine and its evaluation for melanoma in combination with radiotherapy
Cancer is the second leading cause of death in the world and melanoma is the deadliest type of skin cancer. Although surgery, radiotherapy and chemotherapy are still standard treatments, the discovery of the role played by the immune system in cancer has a ...
EPFL2018The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, the generation of nitric oxide, and pain(1,2). ...
NATURE PUBLISHING GROUP2018