Time course of bone screw fixation following a local delivery of zoledronate in a rat femoral model – a micro-finite element analysis

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Calcium phosphate formation on titanium-based surfaces: bioactivity evaluated by in vitro methods

The prediction of implant behaviors in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. In the field of bone implants, it is commonly accepted that a spontaneous formation of a hydroxyapatite (HA) layer on ...

EPFL2018

Effect of a collar on subsidence and local micromotion of cementless femoral stems: in vitro comparative study based on micro-computerised tomography

Dominique Pioletti, Alexandre Terrier, Valérie Hélène Emilie Malfroy Camine

Purpose The aim of this study is to quantitatively compare the difference in primary stability between collarless and collared versions of the same femoral stem. Specifically, we tested differences in subsidence and micromotion. Methods Collarless and coll ...

2018

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Fixed and mobile-bearing total ankle prostheses: Effect on tibial bone strain

Alexandre Terrier, Xavier Crevoisier, Caroline Sieger Fernandes, Maïka Réane Guillemin

Background Total ankle replacement is associated to a high revision rate. To improve implant survival, the potential advantage of prostheses with fixed bearing compared to mobile bearing is unclear. The objective of this study was to test the hypothesis th ...

Elsevier2017

Micromotion-induced peri-prosthetic fluid flow around a cementless femoral stem

Dominique Pioletti, Alexandre Terrier, Valérie Hélène Emilie Malfroy Camine

Micromotion-induced interstitial fluid flow at the bone-implant interface has been proposed to play an important role in aseptic loosening of cementless implants. High fluid velocities are thought to promote aseptic loosening through activation of osteocla ...

Taylor & Francis2017

Importance of trabecular anisotropy in finite element predictions of patellar strain after Total Knee Arthroplasty

Dominique Pioletti, Alexandre Terrier, Adeliya Latypova

Patellar fracture and anterior knee pain remain major complications after Total Knee Arthroplasty (TKA). Patient-specific finite element (FE) models should help improve understanding of these complications through estimation of joint and bone mechanics. Ho ...

Elsevier2017

Human bone progenitor cells for clinical application: what kind of immune reaction does fetal xenograft tissue trigger in immuno-competent rats?

Dominique Pioletti, Lee Ann Laurent-Applegate, Tanja Cloé Hausherr

The potential of human fetal bone cells for successful bone regeneration has been shown in vivo. In particular, it has been demonstrated that the seeding of these cells in porous poly-(L-lactic acid)/ ß-tricalcium phosphate scaffolds improved the bone form ...

Cognizant Communication Corp2017

Ectopic tissue engineered ligament with silk collagen scaffold for ACL regeneration: A preliminary study

Dominique Pioletti, Wei Zhang, Weiliang Shen, Jiayun Huang

Anterior cruciate ligament (ACL) reconstruction remains a formidable clinical challenge because of the lack of vascularization and adequate cell numbers in the joint cavity. In this study, we developed a novel strategy to mimic the early stage of repair in ...

Elsevier2017

Implant-based three-dimensional superimposition of the growing mandible in a rabbit model

The reliable assessment of craniofacial morphological changes during growth requires invariant regions for image registration. As these regions have not yet been identified in three dimensions, intra-osseous implants are required as fiducial markers for th ...

Oxford Univ Press2016

Full-field measurement of micromotion around a cementless femoral stem using micro-CT imaging and radiopaque markers

Dominique Pioletti, Alexandre Terrier, Valérie Hélène Emilie Malfroy Camine, Hannes Andreas Rüdiger

A good primary stability of cementless femoral stems is essential for the long-term success of total hip arthroplasty. Experimental measurement of implant micromotion with linear variable differential transformers is commonly used to assess implant primary ...

Elsevier2016

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Calcium phosphate formation on titanium-based surfaces: bioactivity evaluated by in vitro methods

Weitian Zhao

EPFL2018

Effect of a collar on subsidence and local micromotion of cementless femoral stems: in vitro comparative study based on micro-computerised tomography

Dominique Pioletti, Alexandre Terrier, Valérie Hélène Emilie Malfroy Camine

2018

Human bone progenitor cells for clinical application: what kind of immune reaction does fetal xenograft tissue trigger in immuno-competent rats?

Dominique Pioletti, Lee Ann Laurent-Applegate, Tanja Cloé Hausherr

Cognizant Communication Corp2017