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Corrinoid auxotrophy in the obligate organohalide-respiring Dehalobacter restrictus strain PER-K23

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GuavaH: a compendium of host genomic data in HIV biology and disease

Jacques Fellay, Amalio Telenti, Istvan Bartha

Background: There is an ever-increasing volume of data on host genes that are modulated during HIV infection, influence disease susceptibility or carry genetic variants that impact HIV infection. We created GuavaH (Genomic Utility for Association and Viral ...

BioMed Central2014

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Dehalobacter restrictus strain PER-K23 is an obligate organohalide respiring microorganism known to solely use tetra- or trichloroethene as electron acceptors with H2 as electron donor. The catalytic enzyme, PceA, contains a corrinoid as cofactor, a trait ...

2014

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Background Corrinoids are an essential cofactor of reductive dehalogenases, the key enzymes of the environmental-friendly process of organohalide respiration (OHR). Dehalobacter restrictus strain PER-K23 is an obligate OHR bacterium (OHRB) able to conserve ...

2013

Corrinoid auxotrophy in the obligate organohalide respiring Dehalobacter restrictus

Christof Holliger, Julien Maillard, Aamani Rupakula Boyanapalli, Hauke Smidt

Corrinoids (derivatives of vitamin B12) are an essential cofactor of reductive dehalogenases, the key enzymes involved in the environmental-friendly process of organohalide respiration (OHR). However, genomic and physiological analyses of obligate OHR bact ...

2013

Corrinoid auxotrophy in the obligate organohalide-respiring Dehalobacter restrictus

Christof Holliger, Aamani Rupakula Boyanapalli

2013

Diversity of cobalamin riboswitches in the corrinoid-producing organohalide respirer Desulfitobacterium hafniense

Christof Holliger, Julien Maillard, Emmanuelle Rohrbach, Aurélie Duret

The strategic adaptation of prokaryotes in polluted niches involves the efficient regulation of their metabolism. The obligate anaerobe and metabolically versatile Desulfitobacterium hafniense reductively dechlorinates halogenated organic compounds (so-cal ...

Amer Soc Microbiology2013

A vitamin B-12 transporter in Mycobacterium tuberculosis

John McKinney

Vitamin B-12-depende enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B-12 in vitro, it is uncertain whether the org ...

Royal Society, The2013

Common Mechanisms for Calorie Restriction and AC5 Knockout Models of Longevity

Johan Auwerx

Adenylyl cyclase type 5 knockout mice (AC5 KO) live longer and are stress resistant, similar to calorie restriction (CR). AC5 KO mice eat more, but actually weigh less and accumulate less fat compared to WT mice. CR applied to AC5 KO result in rapid decrea ...

Wiley-Blackwell2012

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Corrinoids (e.g. vitamin B12, cobalamin) represent a family of complex organometallic cofactors essential to the metabolism of microorganisms, animal and humans, and are involved in several enzymes such as isomerases, methyltransferases and reductive dehal ...

2012

The genome of Dehalobacter restrictus - high gene redundancy for a restricted metabolism

Christof Holliger, Julien Maillard, Aamani Rupakula Boyanapalli, Hauke Smidt

Organohalide respiration (OHR) is a bacterial anaerobic respiratory metabolism dedicated to use halogenated compounds as terminal electron acceptors. OHR bacteria are strictly anaerobic microorganisms which use reductive dehalogenases (RdhA) as key enzymes ...

2012