Publication
Fingerprinting the Tertiary Structure of Electroadsorbed Lysozyme at Soft Interfaces by Electrostatic Spray Ionization Mass Spectrometry
Related publications (32)
Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket
Ursula Röthlisberger, Hilal Lashuel, Florence Pojer, Bruno Claude Daniel Fauvet, Michele Cascella, Marilisa Neri, Magdalena Zweckstetter, Hajer Ouertatani-Sakouhi, Farah El Turk, Min Kyu Cho, Amer Ashrafi
Macrophage Migration Inhibitory Factor (MIF) is a key mediator of inflammatory responses and innate immunity and has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. The oligomerization of MIF, more specifically trimer f ...
Public Library of Science2012Approximation Algorithms for the Interval Constrained Coloring Problem
We consider the interval constrained coloring problem, which appears in the interpretation of experimental data in biochemistry. Monitoring hydrogen-deuterium exchange rates via mass spectroscopy experiments is a method used to obtain information about pro ...
2011Enantiopure, monodisperse alleno-acetylenic oligomers, and cyclooligomers
Enantiopure 1,3-diethynylallenes were used as monomers in the construction of monodisperse oligomers and cyclooligomers. The open-chain structures show a non-linear increase in the intensity of the chiroptical properties as the no. of monomeric units incre ...
American Chemical Society2011Vibrational entropy and the structural organization of proteins
Paolo De Los Rios, Francesco Piazza
In this paper we analyze the vibrational spectra of a large ensemble of non-homologous protein structures by means of a novel tool, that we coin Hierarchical Network Model (HNM). Our coarse-grained scheme accounts for the intrinsic heterogeneity of force c ...
2010A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
Hilal Lashuel, Bruno Claude Daniel Fauvet, Magdalena Zweckstetter, Hajer Ouertatani-Sakouhi, Farah El Turk
Macrophage migration inhibitory factor (MIF) is a homotrimeric multifunctional proinflammatory cytokine that has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. Current therapeutic strategies for targeting MIF focus on ...
American Chemical Society2009Supramolecular structures of polypeptides
The formation of supramolecular structures is a central issue in bio- and nanotechnology and therein plays an important role for many novel developments such as biocompatible materials for integrating living cells or coating for implantable sensing devices ...
EPFL2008New methods for the investigation of RNA refolding by NMR spectroscopy
A detailed characterization of the time scales and mechanisms by which RNA molecules change their folding structure upon binding of metabolites or during catalysis is important for the understanding of the different biological functions of RNA. The folding ...
EPFL2006Le concept switch-peptides
Conformational transitions have found broad interest due to their impact on protein misfolding and self-assembly as key events leading to the development of neurodegenerative diseases. However, investigation of these dynamic events has been limited so far ...
EPFL2006The fourth helical secondary structure of β-peptides: The (P)-28-helix of a β-hexapeptide consisting of (2R,3S)-3-amino-2-hydroxy acid residues
The authors report compelling evidence for the formation of a fourth type of helical secondary structure of a beta-peptide in MeOH, and this phenomenon occurs if each amino acid has a hydroxy group in the 2-position. 2D-NMR expts. of terminally-protected b ...
2003Downscaling Fourier Transform Infrared Spectroscopy to the Micrometer and Nanogram Scale: Secondary Structure of Serotonin and Acetylcholine Receptors
Horst Vogel, Rudolf Hovius, Horst Pick, Per Rigler, Erwin Ilegems
High signal-to-noise Fourier transform IR (FTIR) spectra of the 5-hydroxytryptamine (serotonin) receptor (5-HT3R) and the nicotinic acetylcholine receptor (nAChR) were obtained by microscope FTIR spectroscopy using micrometer-sized, fully hydrated protein ...
2003