Publication
Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors
Related publications (93)
Hydrogel Microfluidics to Control Stem Cell Fate
Biomolecular signaling is of utmost importance in governing many biological processes such as morphogenesis during tissue development where biomolecules regulate key cell-fate decisions. In vivo, these factors are presented in a spatiotemporally tightly co ...
EPFL2012Mechanotransduction of epiphyseal chondro-progenitors in 3D hydrogel system.
Of the many external factors that affect cell behavior, mechanical cues are fundamental in modulating a cell’s phenotype. Biomimetic mechanosensing requires the three-dimensional encapsulation of cells within a controlled microenvironment. As musculoskelet ...
2012Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration
Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar
The regeneration of large bone defects caused by trauma or disease remains a significant clinical problem. Although osteoinductive growth factors such as bone morphogenetic proteins have entered clinics, transplantation of autologous bone remains the gold ...
Elsevier Science Bv2012Characterization of the paracrine stimulation potential of human CAP cells for cardiac repair
According to the last WHO numbers, cardiac diseases remain the first cause of death in the world. Cell therapy represents a promising approach to restore heart function. Cardiac derived adherent proliferation (CAP) cells were shown to support the heart reg ...
2011Regulation of proliferation and differentiation of human fetal bone cells
During the last decade, extensive research has been performed in the field of orthopedic medicine to develop cell-based therapies for the restoration of injured bone tissue. We previously demonstrated that human primary fetal bone cells (HFBCs) associated ...
2011Effect of fluid flow shear stress on Mesenchymal Stem Cells(MSC) differentiation using a microfluidic device
Mesenchymal Stem Cells (MSC) are multipotent stem cells that are predominantly obtained from the bone marrow. These cells have a high ability to differentiate into a multitude of cell types, which are very attractive for tissue engineering and cell therapy ...
2011Bone regeneration and stem cells
This invited review covers research areas of central importance for orthopaedic and maxillofacial bone tissue repair, including normal fracture healing and healing problems, biomaterial scaffolds for tissue engineering, mesenchymal and foetal stem cells, e ...
2011Development of a microfluidic on-chip reverse transcription module for the analysis of hematopoietic single stem cells
Hematopoietic stem cells (HSCs) have a unique ability to self-renew and produce differentiated progeny throughout the entire life of the human body. However, present clinical use of HSCs in regenerative medicine is largely hindered by our limited understan ...
2011Investigation of Integrin Expression in Human Mesenchymal Stem Cells during Chondrogenesis in Different Culture Systems
Cartilage tissue engineering aims to develop a material that can be implanted with cells to repair damage in articular cartilage. The extracellular matrix is known to play a key role in regulating stem cell behaviour via cell-matrix interactions and integr ...
2011Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing
Jeffrey Alan Hubbell, Mikaël Martino, Federico Tortelli, Mayumi Mochizuki Martino
Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...
2011