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Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Related publications (59)

Principles of Network Plasticity in Neocortical Microcircuits

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

EPFL2023

Long-term plasticity induces sparse and specific synaptic changes in a biophysically detailed cortical model

Eilif Benjamin Muller, Michael Reimann, James Gonzalo King, Marwan Muhammad Ahmed Abdellah, Pramod Shivaji Kumbhar, András Ecker, Sirio Bolaños Puchet, James Bryden Isbister, Daniela Egas Santander, Jorge Blanco Alonso, Giuseppe Chindemi, Ioannis Magkanaris

Synaptic plasticity underlies the brain’s ability to learn and adapt. This process is often studied in small groups of neurons in vitro or indirectly through its effects on behavior in vivo. Due to the limitations of available experimental techniques, inve ...

2023

Neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently ...

NATL ACAD SCIENCES2022

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Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...

2022

Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2 alpha HRI kinase

Eva Ramos Fernandez

Wnt signaling plays a key role in neurodevelopment and neuronal maturation. Specifically, Wnt5a stimulates postsynaptic assemblies, increases glutamatergic neurotransmission and, through calcium signaling, generates nitric oxide (NO). Trying to unveil the ...

NATURE RESEARCH2021

Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

Graham Knott

Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic plasticity and behavioral deficits in AD is not known. Here, we show that th ...

CELL PRESS2020

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Ursula Röthlisberger, Siri Camee van Keulen, Daniele Narzi, Paolo Carloni

Author summary Adenylyl cyclases (ACs) are enzymes that can translate extracellular signals into the intracellular molecule cAMP, which is thus a 2nd messenger of extracellular events. The brain expresses nine membrane-bound AC variants, and AC5 is the dom ...

PUBLIC LIBRARY SCIENCE2019

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Pierre Magistretti, Igor Allaman, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser

L-Lactate is a positive modulator of NMDAR-mediated signaling resulting in plasticity gene induction and memory consolidation. However, L-Lactate is also able to protect neurons against excito-toxic NMDAR activity, an indication of a mitigating action of L ...

NATURE PUBLISHING GROUP2018

Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism

Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Shiqi Sun

Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...

2018

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Maria del Carmen Sandi Perez, Graham Knott, Johannes Gräff, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Elias Georges Gebara, Jose Vicente Sanchez Mut, Catherine Maclachlan, Wei Tang, Bianca Ambrogina Silva, Alexandre Claude Gustave Bacq

Aggression is frequently observed in neurodevelopmental psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying mechanisms, effective treatments for abnormal aggression are still missing. ...

2018

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