Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival
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The transport of lactate is an essential part of the concept of metabolic coupling between neurons and glia. Lactate transport in primary cultures of astroglial cells was shown to be mediated by a single saturable transport system with a Km value for lacta ...
With use of a modified surface coil technique, the authors recorded phosphorus-31 magnetic resonance (MR) spectra of the brains of 40 neonates and infants (48 examinations) ranging from 33 weeks postconceptional age to 6 years of age. Signals of phosphorus ...
The growth physiol. of S. cerevisiae strains H1022 and Whi2+ was studied in aerobic batch and continuous (chemostat) cultures. Results from the measurement of biomass and medium components (off-line) together with O2, CO2, and heat measurements (online) we ...
Aerobic chemostat cultures of S. cerevisiae were performed at different diln. rates under energy (glucose) limitation or at various extents of energy excess imposed by a N limitation. Energy excess induced metabolic uncoupling under steady-state conditions ...
Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 microM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP. Application of ...
The effect of diln. rate on the prodn. of lactic acid from whey permeate by L. helveticus was investigated. In the 1st chemostat of a 2-stage system, total conversion (98.1%) and max. lactic acid concn. (43.7 g/L) were obtained at a diln. rate (D1tot) of 0 ...
Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes neurons by acting at specific receptors. Its action is terminated by removal from the synaptic cleft mostly via Na(+)-dependent uptake systems located on bo ...
To study intramitochondrial phospholipid flow, radiolabeled phosphatidylserine was introduced into isolated rat liver mitochondria from donor vesicles through the action of a nonspecific lipid transfer protein. Imported phosphatidylserine was rapidly decar ...
American Society for Biochemistry and Molecular Biology1992