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As of today, dissolution Dynamic Nuclear Polarization (dDNP) is the only clinically available hyperpolarization technique for C-13-MRI. Despite the clear path towards personalized medicine that dDNP is paving as an alternative and/or complement to Positron ...
NATURE PORTFOLIO2022
The intense but transient increase in nuclear magnetic resonance signal provided by dynamic nuclear polarization (DNP) has enabled a range of new applications, including rapid, minimally-invasive metabolic imaging at the second timescale. This chapter prov ...
Academic Press2021
MR is a well-established technique routinely used in preclinical and clinical studies. This thesis focussed on the improvement of sensitivity of different methods in MR.Hyperpolarized 129Xe gas is used for studying pulmonary disease or cerebral perfusion ...
EPFL2021
Dynamic Nuclear Polarization (DNP) is, nowadays, the most well-established and widespread Nuclear Magnetic Resonance (NMR) hyperpolarization technique. With respect to other methods, the main advantage of DNP is, with no doubt, its versatility. In theory e ...
EPFL2016
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Poly(triazine imide) or PTI is a promising material for molecular sieving membranes, thanks to its atom-thick ordered lattice with an extremely high density (1.6 x 10(14)pores per cm(2)) of triangular-shaped nanopores of similar to 0.34 nm diameter. Here, ...
2020
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129Xe dissolution dynamic nuclear polarization (DNP) is a controversial topic. The gold standard technique for hyperpolarized xenon magnetic resonance imaging (MRI) is spin exchange optical pumping, which received FDA approval in 2022. Nevertheless, the ve ...
2024
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Enhancing the sensitivity of magnetic resonance spectroscopy/imaging (MRS/MRI) by dissolution dynamic nuclear polarization (dDNP) has expanded the scope of MRS applications to new fields of research. Most importantly, it has paved the way toward noninvasiv ...
The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using ...
Xenon is known to be a very efficient anesthetic gas, but its cost prohibits the wider use in medical industry and other potential applications. It has been shown that Xe recovery and recycling from anesthetic gas mixtures can significantly reduce its cost ...
Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation o ...
