Computational anatomyComputational anatomy is an interdisciplinary field of biology focused on quantitative investigation and modelling of anatomical shapes variability. It involves the development and application of mathematical, statistical and data-analytical methods for modelling and simulation of biological structures. The field is broadly defined and includes foundations in anatomy, applied mathematics and pure mathematics, machine learning, computational mechanics, computational science, biological imaging, neuroscience, physics, probability, and statistics; it also has strong connections with fluid mechanics and geometric mechanics.
Analytic manifoldIn mathematics, an analytic manifold, also known as a manifold, is a differentiable manifold with analytic transition maps. The term usually refers to real analytic manifolds, although complex manifolds are also analytic. In algebraic geometry, analytic spaces are a generalization of analytic manifolds such that singularities are permitted. For , the space of analytic functions, , consists of infinitely differentiable functions , such that the Taylor series converges to in a neighborhood of , for all .
Explained variationIn statistics, explained variation measures the proportion to which a mathematical model accounts for the variation (dispersion) of a given data set. Often, variation is quantified as variance; then, the more specific term explained variance can be used. The complementary part of the total variation is called unexplained or residual variation. Following Kent (1983), we use the Fraser information (Fraser 1965) where is the probability density of a random variable , and with () are two families of parametric models.
