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ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

Related publications (33)

Dissecting Gene Regulatory Networks Using Targeted Quantitative Proteomics

Gene regulatory networks control gene expression levels, and therefore play an essential role in mammalian development and function. Regulation of gene expression is the result of a complex interplay between DNA regulatory elements and their binding partne ...

EPFL2012

Human-Specific Histone Methylation Signatures at Transcription Start Sites in Prefrontal Neurons

Jeffrey David Jensen

Cognitive abilities and disorders unique to humans are thought to result from adaptively driven changes in brain transcriptomes, but little is known about the role of cis-regulatory changes affecting transcription start sites (TSS). Here, we mapped in huma ...

Public Library Science2012

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Richardus Houtkooper, Hiroyasu Yamamoto

SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to ...

Elsevier2011

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.

Johan Auwerx, Walter Wahli, Liliane Michalik

The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology with all members of the superfamily, particularly in the D ...

2006

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma

Johan Auwerx, Kristina Schoonjans

In a systematic search for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) target genes, we identified S3-12 and perilipin as novel direct PPAR-gamma target genes. Together with adipophilin and tail-interacting protein of 47 kDa, these genes ...

2004

Adipose tissue: New therapeutic targets from molecular and genetic studies - IASO Stock Conference 2003 report

Johan Auwerx

This review highlights the presentations and discussions held during the 2003 Stock Conference in Lisbon focussed on the identification of new therapeutic targets for the treatment of obesity and identified through molecular and genetic studies. Transcript ...

2004

A gateway-compatible yeast one-hybrid system

Bart Deplancke

Since the advent of microarrays, vast amounts of gene expression data have been generated. However, these microarray data fail to reveal the transcription regulatory mechanisms that underlie differential gene expression, because the identity of the respons ...

2004

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice

Johan Auwerx

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPAR gamma 2-specific exon B, resulting in a white adipose tissue knockdown of PPAR ...

2003

PPAR(gamma) and glucose homeostasis

Johan Auwerx

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor involved in the control of metabolism. Research on PPARgamma is oriented towards understanding its role in insulin sensitization, which was inspired by the discovery that an ...

2002

Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases

Johan Auwerx

The peroxisome proliferator-activated receptor gamma (PPARgamma) and its partner the retinoid X receptor (RXR) are two nuclear receptors that are expressed mainly in adipose tissue and which have a role in lipid metabolism and insulin sensitisation. New si ...

2002

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