Chemical functionalization of bio-ceramics to enhance endothelial cells adhesion for tissue engineering

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Cell Guidance on Nanogratings: A Computational Model of the Interplay between PC12 Growth Cones and Nanostructures

Background: Recently, the effects of nanogratings have been investigated on PC12 with respect to cell polarity, neuronal differentiation, migration, maturation of focal adhesions and alignment of neurites. Methodology/Principal Findings: A synergistic proc ...

Public Library Science2013

An actin length threshold regulates adhesion maturation at the lamellipodium/lamellum interface

Jean-Jacques Meister, Benoît Vianay, Céline Jeanne Labouesse

The mechanical coupling between adherent cells and their substrates is a major driver of downstream behavior. This coupling relies on the formation of adhesion sites and actin bundles. How cells generate these elements remains only partly understood. A pot ...

Royal Soc Chemistry2013

Development of thermoplastic coated multifunctional transmission elements

Véronique Michaud, Basile Golaz

We report on key challenges of the development of steel cords reinforced thermoplastic elastomer composites with smart functionalities: adhesion tailoring for a durable mechanical load transfer through steel cords or other transmission elements by the use ...

Society of Photo-Optical Instrumentation Engineers (SPIE)2012

In vitro lymphatic endothelial morphogenesis : molecular vs. biophysical regulation

Carolyn Yong Pullin

Cell organization into functional multicellular three-dimensional structures is a long-standing challenge. In particular, engineering of vascularized tissues requires both blood and lymphatic neovascular network formation in a simultaneous and coordinated ...

EPFL2011

Cell-Matrix Adhesion: Slip and Immobilization under Force

Alexander Verkhovskiy

When force is applied to cell-matrix adhesion complexes, they respond by growing larger and stronger. It emerges that strengthening involves transient motion of the transmembrane integrin receptors and their eventual immobilization to the extracellular mat ...

Elsevier2010

Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

Maria del Carmen Sandi Perez

Neuroplastin (Np) is a glycoprotein belonging to the immunoglobulin superfamily of cell adhesion molecules (CAMs) and existing in two isoforms, Np55 and Np65, named according to their molecular weights. The extracellular part of Np65 contains three immunog ...

Federation of American Society of Experimental Biology2010

Dennexin peptides modeled after the homophilic binding sites of the neural cell adhesion molecule (NCAM) promote neuronal survival, modify cell adhesion and impair spatial learning

Maria del Carmen Sandi Perez, Martina Fantin

Neural cell adhesion molecule (NCAM)-mediated cell adhesion results in activation of intracellular signaling cascades that lead to cellular responses such as neurite outgrowth, neuronal survival, and modulation of synaptic activity associated with cognitiv ...

2010

Experimentation on adhesion of epoxy

Alain Curnier, Aleksandar Sekulic

In a recent article (Sekulic and Curnier (2007) [1]), an original axisymmetric epoxy-stamp on glass-disc specimen, which exhibits stable debonding, was presented for identifying the adhesive properties between epoxy and glass, namely interface debonding en ...

2010

3D collagen cultures under well-defined dynamic strain: A novel strain device with a porous elastomeric support

Melody Swartz, Alice Anna Tomei, Federica Boschetti

The field of mechanobiology has grown tremendously in the past few decades, and it is now well accepted that dynamic stresses and strains can impact cell and tissue organization, cell-cell and cell-matrix communication, matrix remodeling, cell proliferatio ...

Wiley-Blackwell2009

Adhesion failures on hard coatings induced by interface anomalies

Silviu Cosmin Sandu

In this work, the lack of adhesion occurred during the up-scaling of the deposition of tribological coatings in a semi-industrial apparatus is interpreted. The adhesion problems were detected for both hard and self-lubricant coatings from W–Ti–N and W:C sy ...

2009

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Dennexin peptides modeled after the homophilic binding sites of the neural cell adhesion molecule (NCAM) promote neuronal survival, modify cell adhesion and impair spatial learning

Maria del Carmen Sandi Perez, Martina Fantin

2010