Publication
De l'usage des protons hyperpolarisés pour augmenter la sensibilité de la RMN
Related publications (159)
Single Chip Dynamic Nuclear Polarization Microsystems
Nuclear magnetic resonance (NMR) methods are powerful tools employed in many fields, including physics, chemistry, material science, biology, and medicine. The use of NMR methodologies in an even wider range of applications is often hindered by the relativ ...
EPFL2023Fast, Broad-Band Magnetic Resonance Spectroscopy with Diamond Widefield Relaxometry
Mayeul Sylvain Chipaux, Hoda Shirzad
We present an alternative to conventional Electron the use of bulky magnets and magnetron equipment, we use the photoluminescence of an ensemble of Nitrogen-Vacancy centers at the surface of a diamond. Monitoring their relaxation time (or T1), we detected ...
AMER CHEMICAL SOC2023Multi-sample/multi-nucleus parallel polarization and monitoring enabled by a fluid path technology compatible cryogenic probe for dissolution dynamic nuclear polarization
Andrea Capozzi, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê
Low throughput is one of dissolution Dynamic Nuclear Polarization (dDNP) main shortcomings. Especially for clinical and preclinical applications, where direct 13C nuclei polarization is usually pursued, it takes hours to generate one single hyperpolarized ...
2023Diamond-Based Nanoscale Quantum Relaxometry for Sensing Free Radical Production in Cells
Mayeul Sylvain Chipaux, Hoda Shirzad
Diamond magnetometry makes use of fluorescent defects in diamonds to convert magnetic resonance signals into fluorescence. Because optical photons can be detected much more sensitively, this technique currently holds several sensitivity world records for r ...
WILEY-V C H VERLAG GMBH2022H-1 Hyperpolarization of Solutions by Overhauser Dynamic Nuclear Polarization with C-13-H-1 Polarization Transfer
David Lyndon Emsley, Yu Rao, Pinelopi Moutzouri, Amrit Venkatesh
Dynamic nuclear polarization (DNP) is a method that can significantly increase the sensitivity of nuclear magnetic resonance. The only effective DNP mechanism for in situ hyperpolarization in solution is Overhauser DNP, which is inefficient for H-1 at high ...
AMER CHEMICAL SOC2022Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions
Jean-Philippe Thiran, Friedhelm Christoph Hummel, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Gabriel Girard, Elda Fischi Gomez, Marco Pizzolato, Gian Franco Piredda, Thomas Yu, Takuya Morishita, Elena Beanato, Alessandro Daducci, Maximilian Jonas Wessel, Chang-Hyun Park, Philipp Johannes Koch, Andéol Geoffroy Cadic-Melchior, Julia Brügger
Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acqu ...
2022Performance and reproducibility of C-13 and N-15 hyperpolarization using a cryogen-free DNP polarizer
Hikari Ananda Infinity Yoshihara, Arianna Ferrari
The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using ...
NATURE PORTFOLIO2022Solid-state NMR spectroscopy
Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This Primer summarizes the basic principles of NMR spectroscopy as applied to the ...
SPRINGERNATURE2021Hyperpolarization of inorganic solids
Solid-state NMR can provide information about the atomic level structure and dynamics of materials. It directly probes symmetry and structure at nuclear sites, and is especially useful for investigation of disordered or amorphous solids that lack long rang ...
EPFL2021Mechanistic studies of DNP and applications of hyperpolarized probes to study renal physiology and metabolism
Dissolution dynamic nuclear polarization (dDNP) is a powerful technique that enhances the magnetic resonance signal of nuclear spins by several orders of magnitude. DNP relies on the principle of cross-relaxation by electron spins driven out of equilibrium ...
EPFL2021