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A versatile clearing agent for multi-modal brain imaging
Related publications (35)
X-ray imaging detector for radiological applications adapted to the context and requirements of low- and middle-income countries
Jean-Philippe Thiran, René Salathé, Klaus Benedikt Schönenberger, Jérôme Schmid, Mario Andres Chavarria Varon, Hubert Blanchard, Romain Sahli, Sébastien Emmanuel Blanc, Matthias Hüser
This paper describes the development of a novel medical x-ray imaging system adapted to the needs and constraints of low- and middle-income countries. The developed system is based on an indirect conversion chain: a scintillator plate produces visible ligh ...
2022Polarization-sensitive optics diffraction tomography
Demetri Psaltis, Joowon Lim, Elizabeth Elena Antoine, Amirhossein Saba Shirvan, Ahmed Ayoub
Polarization of light has been widely used as a contrast mechanism in two-dimensional (2D) microscopy and also in some three-dimensional (3D) imaging modalities. In this paper, we report the 3D tomographic reconstruction of the refractive index (RI) tensor ...
OPTICAL SOC AMER2021Computational methods for live heart imaging with speed-constrained microscopes
Imaging methods to capture the beating and developing heart inside embryonic animal models such as the zebrafish are a key component for the study of fundamental biological processes such as cardiac birth defects or tissue regeneration. However, live heart ...
EPFL2021Systematic Tuning of Rhodamine Spirocyclization for Super-resolution Microscopy
Rhodamines are the most important class of fluorophores for applications in live-cell fluorescence microscopy. This is mainly because rhodamines exist in a dynamic equilibrium between a fluorescent zwitterion and a nonfluorescent but cell-permeable spirocy ...
AMER CHEMICAL SOC2021High-throughput and adaptive super-resolution fluorescence microscopy of organelles
Fluorescence super-resolution microscopy has allowed unprecedented insight into the workings of biological systems below the diffraction limit of light. Over the past decade, it has overcome several challenges to deliver 3D, multi-color and faster imaging ...
EPFL2020Aliasing mitigation in optical microscopy of dynamic biological samples by use of temporally modulated color illumination and a standard RGB camera
Michael Stefan Daniel Liebling, Christian Jaques
Significance: Despite recent developments in microscopy, temporal aliasing can arise when imaging dynamic samples. Modern sampling frameworks, such as generalized sampling, mitigate aliasing but require measurement of temporally overlapping and potentially ...
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS2020Temporal resolution doubling in fluorescence light-sheet microscopy via a hue-encoded shutter and regularization
Michael Stefan Daniel Liebling, Christian Jaques
Studying dynamic biological processes, such as heart development and function in zebrafish embryos, often relies on multi-channel fluorescence labeling to distinguish multiple anatomical features, yet also demands high frame rates to capture rapid cell mot ...
2020Development of novel experimental and computational methods for three-dimensional coherent and super-resolution microscopy
Adrien Charles-François Raymond Descloux
Optical microscopy is one widely used tool to study cell functions and the interaction of molecules at a sub-cellular level. Optical microscopy techniques can be broadly divided into two categories: partially coherent and incoherent. Coherent microscopy te ...
EPFL2020Optical projection tomography for whole organ imaging
In the past twenty years, far-reaching studies of molecular and cellular processes have reached a milestone in their maturation, and the knowledge from these studies was ready to apply at higher organizational levels. At that time, rodent models were long ...
EPFL2019Three-dimensional imaging of integrated circuits with macro- to nanoscale zoom
Gabriel Aeppli, Manuel Guizar Sicairos, Christian David, Michal Odstrcil
The imaging of integrated circuits across different length scales is required for failure analysis, design validation and quality control. At present, such inspection is accomplished using a hierarchy of different probes, from optical microscopy on the mil ...
NATURE PUBLISHING GROUP2019