Kinetics of Ultrasonic Drug Delivery from Targeted Micelles
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The U3 box C/D snoRNA is one key element of 90S pre-ribosome. It contains a 5' domain pairing with pre-rRNA and the U3(B/C) and U3(C'/D) motifs for U3 packaging into a unique small nucleolar ribonucleoprotein particle (snoRNP). The RNA-binding protein Snu1 ...
A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that already exist on the market may offer an attractive alternative. Here we report on a new model-based streamlined feedback system control (s-FSC) method, based on a ...
Background: Social media platforms are increasingly seen as a source of data on a wide range of health issues. Twitter is of particular interest for public health surveillance because of its public nature. However, the very public nature of social media pl ...
Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting an ...
Diffusion-controlled hydrogel polymeric matrix devices have been among the most widely used drug delivery systems. How ever in homogeneous hydrogel the diffusional distance increase with time and hence, the release rate decreases. That results in high rele ...
HEMA hydrogels are hydrophobic biocompatible hydrogel with high mechanical and viscoelastic properties, which are widely used in biomedical application including drug delivery systems. The mechanical properties and permeability of these hydrogels can be tu ...
We show numerically that the response of simple amorphous solids (elastic networks and particle packings) to a local force dipole is characterized by a lengthscale c that diverges as unjamming is approached as c ∼ (z - 2d)-1/2, where z ≥ 2d is the mean coo ...
This article contributes a highly accurate model for predicting the melting points (MPs) of medicinal chemistry compounds. The model was developed using the largest published data set, comprising more than 47k compounds. The distributions of MPs in drug-li ...
Building a personalized model to describe the drug concentration inside the human body for each patient is highly important to the clinical practice and demanding to the modeling tools. Instead of using traditional explicit methods, in this paper we propos ...
The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side ...