Publication

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord

Related publications (32)

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG digesti ...

Society for Neuroscience2014

Neuroprosthetic rehabilitation and translational mechanism after severe spinal cord injury

Lucia Florinda Friedli Wittler

Traumatic SCIs have long-term health, economic and social consequences, stressing the urgency to develop interventions to improve recovery after such injuries. Today, the only proven effective interventions to enhance recovery after SCI are activity-based ...

EPFL2014

Simple merging technique for improving resolution in qualitative single image phase contrast tomography

Peter Modregger, Zheng Wang, Marco Stampanoni

For dynamic samples and/or for simple ease-of-use experiments, single-image phase contrast tomography is a very effective method for the 3D visualization of materials which would otherwise be indiscernible in attenuation based x-ray imaging. With binary sa ...

Optical Society of America2014

Multisystem Neuroprosthetic Training Improves Bladder Function After Severe Spinal Cord Injury

Grégoire Courtine, Rubia van den Brand, Daniel Eberli

Severe spinal cord injury leads to neurogenic bladder dysfunction. We recently developed a multisystem neuroprosthetic training program that promotes plastic changes capable of restoring refined locomotion in rats with severe spinal cord injury. We investi ...

Elsevier Science Inc2013

Phase-dependent modulation of percutaneously elicited multisegmental muscle responses after spinal cord injury

Grégoire Courtine

Phase-dependent modulation of monosynaptic reflexes has been reported for several muscles of the lower limb of uninjured rats and humans. To assess whether this step-phase-dependent modulation can be mediated at the level of the human spinal cord, we compa ...

2010

Combinatory electrical and pharmacological neuroprosthetic interfaces to regain motor function after spinal cord injury

Grégoire Courtine, Pavel Musienko, Rubia van den Brand

Severe lesions of the rodent or human spinal cord lead to permanent paralysis of the legs. Here, we review novel evidences suggesting that interventions combining pharmacological and electrical stimulations of the spinal cord have a high potential to promo ...

2009

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

Grégoire Courtine, Pavel Musienko, Rubia van den Brand, Michael V. Sofroniew

After complete spinal cord transections that removed all supraspinal inputs in adult rats, combinations of serotonergic agonists and epidural electrical stimulation were able to acutely transform spinal networks from nonfunctional to highly functional and ...

2009

Hard-X-ray dark-field imaging using a grating interferometer

Christian David

Imaging with visible light today uses numerous contrast mechanisms, including bright- and dark-field contrast, phase-contrast schemes and confocal and fluorescence-based methods. X-ray imaging, on the other hand, has only recently seen the development of a ...

2008

Fabrication of diffraction gratings for hard X-ray phase contrast imaging

Christian David

We have developed a method for X-ray phase contrast imaging, which is based on a grating interferometer. The technique is capable of recording the phase shift of hard X-rays travelling through a sample, which greatly enhances the contrast of low absorbing ...

2007

Grating interferometer based scanning setup for hard x-ray phase contrast imaging

Christian David

In x-ray radiography, particularly for technical and industrial applications, a scanning setup is very often favorable when compared to a direct two-dimensional image acquisition. Here, we report on an efficient scanning method for grating based x-ray phas ...

2007

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