AssayAn assay is an investigative (analytic) procedure in laboratory medicine, mining, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a target entity. The measured entity is often called the analyte, the measurand, or the target of the assay. The analyte can be a drug, biochemical substance, chemical element or compound, or cell in an organism or organic sample.
16-cellIn geometry, the 16-cell is the regular convex 4-polytope (four-dimensional analogue of a Platonic solid) with Schläfli symbol {3,3,4}. It is one of the six regular convex 4-polytopes first described by the Swiss mathematician Ludwig Schläfli in the mid-19th century. It is also called C16, hexadecachoron, or hexdecahedroid . It is a part of an infinite family of polytopes, called cross-polytopes or orthoplexes, and is analogous to the octahedron in three dimensions. It is Coxeter's polytope.
Human leukocyte antigenThe human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for regulation of the immune system. The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. Mutations in HLA genes may be linked to autoimmune diseases such as type I diabetes, and celiac disease. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6, p-arm at 21.3.
24-cell honeycombIn four-dimensional Euclidean geometry, the 24-cell honeycomb, or icositetrachoric honeycomb is a regular space-filling tessellation (or honeycomb) of 4-dimensional Euclidean space by regular 24-cells. It can be represented by Schläfli symbol {3,4,3,3}. The dual tessellation by regular 16-cell honeycomb has Schläfli symbol {3,3,4,3}. Together with the tesseractic honeycomb (or 4-cubic honeycomb) these are the only regular tessellations of Euclidean 4-space. The 24-cell honeycomb can be constructed as the Voronoi tessellation of the D4 or F4 root lattice.
Antinuclear antibodyAntinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some cases, antibodies to human antigens are produced. There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to nuclear pore complexes, anti-centromere antibodies and anti-sp100 antibodies.
Interleukin 12Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35. Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.
DuopyramidIn geometry of 4 dimensions or higher, a double pyramid or duopyramid or fusil is a polytope constructed by 2 orthogonal polytopes with edges connecting all pairs of vertices between the two. The term fusil is used by Norman Johnson as a rhombic-shape. The term duopyramid was used by George Olshevsky, as the dual of a duoprism. The lowest dimensional forms are 4 dimensional and connect two polygons. A p-q duopyramid or p-q'' fusil, represented by a composite Schläfli symbol {p} + {q}, and Coxeter-Dynkin diagram .
InfliximabInfliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, and Behçet's disease. It is given by slow injection into a vein, typically at six- to eight-week intervals. Common side effects include infections, acute infusion reactions, and abdominal pain. Infliximab is a chimeric monoclonal antibody biologic.
Cell theoryIn biology, cell theory is a scientific theory first formulated in the mid-nineteenth century, that organisms are made up of cells, that they are the basic structural/organizational unit of all organisms, and that all cells come from pre-existing cells. Cells are the basic unit of structure in all organisms and also the basic unit of reproduction. The three tenets of the cell theory are: All organisms are composed of one or more cells. The cell is the basic unit of structure and organization in organisms.
Sampling (statistics)In statistics, quality assurance, and survey methodology, sampling is the selection of a subset or a statistical sample (termed sample for short) of individuals from within a statistical population to estimate characteristics of the whole population. Statisticians attempt to collect samples that are representative of the population. Sampling has lower costs and faster data collection compared to recording data from the entire population, and thus, it can provide insights in cases where it is infeasible to measure an entire population.
