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Direct-to-consumer genetic testing makes it possible for everyone to learn their genome sequences. In order to contribute to medical research, a growing number of people publish their genomic data on the Web, sometimes under their real identities. However, ...
We present a new haplotype-based statistic (nS(L)) for detecting both soft and hard sweeps in population genomic data from a single population. We compare our new method with classic single-population haplotype and site frequency spectrum (SFS)-based metho ...
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond hom ...
Stavudine (d4T) was, until recently, one of the most widely prescribed antiretroviral drugs worldwide. While there has been a major shift away from d4T use in resource-limited countries, a large number of patients have previously received (or continue to r ...
Motivation: Comparative genomics aims to understand the structure and function of genomes by translating knowledge gained about some genomes to the object of study. Early approaches used pairwise comparisons, but today researchers are attempting to leverag ...
Background: Body mass index (BMI) may cluster in space among adults and be spatially dependent. Whether BMI clusters among children and how adults and children BMI clusters are related remains unknown. We aimed to identify and to compare BMI spatial depend ...
Despite the vast diversity of sizes and shapes of living organisms, life's organization across scales exhibits remarkable commonalities, most notably through the approximate validity of Kleiber's law, the power law scaling of metabolic rates with the mass ...
Summary Understanding the peopling of the Americas remains an important and challenging question. Here, we present 14C dates, and morphological, isotopic and genomic sequence data from two human skulls from the state of Minas Gerais, Brazil, part of one of ...
The question of finding an appropriate scale to study adaptation emerged only recently in landscape genomics, while in landscape ecology its components (extent and resolution or grain) have been addressed in many papers. In fact, in landscape genetics only ...
Genetic diversity is essential for population survival and adaptation to changing environments. Demographic processes (e.g., bottleneck and expansion) and spatial structure (e.g., migration, number, and size of populations) are known to shape the patterns ...