Protein phosphorylationProtein phosphorylation is a reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become either activated or deactivated, or otherwise modifying its function. Approximately 13000 human proteins have sites that are phosphorylated. The reverse reaction of phosphorylation is called dephosphorylation, and is catalyzed by protein phosphatases.
Protein kinaseA protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. There are two main types of protein kinase.
Gallium phosphateGallium phosphate (GaPO4 or gallium orthophosphate) is a colorless trigonal crystal with a hardness of 5.5 on the Mohs scale. GaPO4 is isotypic with quartz, possessing very similar properties, but the silicon atoms are alternately substituted with gallium and phosphorus, thereby doubling the piezoelectric effect. GaPO4 has many advantages over quartz for technical applications, like a higher electromechanical coupling coefficient in resonators, due to this doubling. Contrary to quartz, GaPO4 is not found in nature.
Special Air ServiceThe Special Air Service (SAS) is a special forces unit of the British Army. It was founded as a regiment in 1941 by David Stirling and in 1950, it was reconstituted as a corps. The unit specialises in a number of roles including counter-terrorism, hostage rescue, direct action and covert reconnaissance. Much of the information about the SAS is highly classified, and the unit is not commented on by either the British government or the Ministry of Defence due to the secrecy and sensitivity of its operations.
