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Learning Approach to Optical Tomography

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Advanced Techniques in Optical Diffraction Tomography

Ahmed Bassam Sayed Ayoub Mohamed Emam

In this thesis, we study the 3 challenges described above. First, we study different reconstruction techniques and assess the fidelity of each reconstruction results by means of structured illumination and phase conjugation. By reconstructing the 3D refrac ...

EPFL2022

3D reconstruction of weakly scattering objects from 2D intensity-only measurements using the Wolf transform

Demetri Psaltis, Joowon Lim, Elizabeth Elena Antoine, Ahmed Ayoub

A new approach to optical diffraction tomography (ODT) based on intensity measurements is presented. By applying the Wolf transform directly to intensity measurements, we observed unexpected behavior in the 3D reconstruction of the sample. Such a reconstru ...

OPTICAL SOC AMER2021

The high longitudinal and lateral coherence of synchrotron X-rays sources radically transformed radiography. Before them, the image contrast was almost only based on absorption. Coherent synchrotron sources transformed radiography into a multi-faceted tool ...

MDPI2021

Brain micro-vasculature imaging: An unsupervised deep learning algorithm for segmenting mouse brain volume probed by high-resolution phase-contrast X-ray tomography

Alessandra Patera, Anne Bonnin, Marco Stampanoni

High-throughput synchrotron-based tomographic microscopy at third generation light sources allows to probe cm-sized samples at micrometer-resolution. In this work, we present an approach to image a full mouse brain. With Indian-ink as a contrast agent, it ...

WILEY2020

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Purpose : Based on oblique partially coherent illumination of transparent samples, we developed a simple custom Optical Phase Imaging (OPI) microscope providing a label-free, semi-quantitative phase contrast imaging. The aim of this study was to explore th ...

ASSOC RESEARCH VISION OPHTHALMOLOGY INC2020

Megapixel time-gated SPAD image sensor for 2D and 3D imaging applications

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Andrei Ardelean, Ming-Lo Wu, Arin Can Ülkü, Kazuhiro Morimoto

We present a 1 Mpixel single-photon avalanche diode camera featuring 3.8 ns time gating and 24 kips frame rate, fabricated in 180 nm CMOS image sensor technology. We designed two pixels with a pitch of 9.4 mu m in 7 T and 5.75 T configurations respectively ...

OPTICAL SOC AMER2020

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

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We propose a disruptive point-of-care (PoC) imaging platform based on lens-free interference phase-contrast imaging for rapid detection of biomarker such as for sepsis and potentially other diseases (e.g. cancer). It enables simultaneous analysis of potent ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Optical tomography has been widely investigated for biomedical imaging applications. In recent years, it has been combined with digital holography and has been employed to produce high quality images of phase objects such as cells. In this Thesis, we look ...

EPFL2018

High-resolution imaging in thick biological tissues beyond a few transport mean free path of photons remains a formidable challenge to modern science and technology. Recent advancements in optical tomography have enabled the reconstruction of the three-dim ...

SPIE-INT SOC OPTICAL ENGINEERING2018