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Impact of Conduction Velocity on Local Capture of Atrial Fibrillation Induced by Rapid Pacing

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Background: Consistently successful patient outcomes following catheter ablation (CA) for treatment of persistent atrial fibrillation (pers-AF) remain elusive. We propose an electrocardiogram (ECG) analysis designed to (1) refine selection of patients most ...

FRONTIERS MEDIA SA2021

Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive o ...

WILEY2020

Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation

Jean-Marc Vesin, Adrian Luca, Sasan Yazdani, Lukas Kappenberger

Objectives The electrocardiogram (ECG) of patients with BrS in sinus rhythm might reflect intrinsic atrial electrical abnormalities independent from any previous atrial fibrillation (AF). Aim of this study is to investigate the presence of P-wave abnormali ...

Elsevier2018

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Computer model-based simulations have shown that rapid stimulation at 60-100% of atrial fibrillation cycle length (AFCL) from a ring of electrodes located around the septum may induce local capture in both atria for most AF dynamics. The present study aims ...

2017

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Introduction: Electrical heterogeneity in the atria has been consistently linked with the initiation and perpetuation of atrial fibrillation (AF). The present model-based study investigated the contribution of action potential duration (APD) heterogeneitie ...

2016

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Oxford Univ Press2016

Introduction: Moving to clinical validation is an essential phase with every model-based result. However, this translation is often not straightforward because animal models differ from human computer models in many anatomic and electrophysiologic ways, wh ...

2016

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Our study aims at determining whether the efficiency of step-wise catheter ablation (step-CA) of persistent atrial fibrillation (pAF) can be tracked using organization indices based on the harmonic components of atrial ECG signals until pAF termination. EC ...

2016

Atrial fibrillation septal pacing: translation of modelling results

Adrian Luca

Aims: Atrial fibrillation (AF) septal pacing consists of rapid pacing from a ring of electrodes around the atrial septum, leading to local capture of both atria during AF. The present model-based study evaluated the impact of the number of stimulation elec ...

Oxford Univ Press2016

Intermittent Atrial Tachycardia Promotes Repolarization Alternans and Conduction Slowing During Rapid Rates, and Increases Susceptibility to Atrial Fibrillation in a Free-Behaving Sheep Model

Jean-Marc Vesin, Florian Jousset, Etienne Pruvot

Repolarization Alternans and Atrial Remodeling Introduction Paroxysmal atrial fibrillation (AF) may be triggered by intermittent atrial tachycardia, and ultimately lead to persistent AF. However, the mechanisms by which intermittent atrial tachycardia prom ...

Wiley-Blackwell2014