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Exploring enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

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New and improved methods for integrated models of metabolism and gene expression

Pierre Guy Rémy Salvy

The beginning of the 21st century was marked by the advent of disruptive technologies, which ushered an era of groundbreaking advances in fundamental sciences, carried by the great pace at which computational capabilities spread and evolved. But the new ce ...

EPFL2021

Emergence of diauxie as an optimal growth strategy under resource allocation constraints in cellular metabolism

Vassily Hatzimanikatis, Pierre Guy Rémy Salvy

Diauxie, or the sequential consumption of carbohydrates in bacteria such as Escherichia coli, has been hypothesized to be an evolutionary strategy which allows the organism to maximize its instantaneous specific growth-giving the bacterium a competitive ad ...

NATL ACAD SCIENCES2021

Soft-probe-scanning electrochemical microscopy reveals electrochemical surface reactivity of E. coli biofilms

Hubert Girault, Emad Oveisi, Horst Pick, Andreas Stephan Lesch, Sorour Darvishi

Investigating and understanding dynamic biofilm growth mechanisms is challenging, often because state-of-theart optical characterization tools provide limited information. Micrometric electrochemical imaging of Escherichia coli biofilms using Soft-Probe-Sc ...

2021

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Investigating and understanding dynamic biofilm growth mechanisms is challenging, often because state-of-the-art optical characterization tools provide limited information. Micrometric electrochemical imaging of Escherichia coli biofilms using Soft-Probe-S ...

2021

Large-scale kinetic metabolic models of Pseudomonas putida KT2440 for consistent design of metabolic engineering strategies

Vassily Hatzimanikatis, Ljubisa Miskovic, Milenko Tokic

Background: Pseudomonas putida is a promising candidate for the industrial production of biofuels and biochemicals because of its high tolerance to toxic compounds and its ability to grow on a wide variety of substrates. Engineering this organism for impro ...

2020

In an effort of overcoming the limited availability of fossil energy resources and moving toward a sustainable economy, the focus of the research and development in the area of biofuels has shifted towards developing the 2nd generation of fuels that should ...

EPFL2019

From Slide Rule to Big Data: How Data Science is Changing Water Science and Engineering

Janet Gordon Hering

Forum papers are thought-provoking opinion pieces or essays founded in fact, sometimes containing speculation, on a civil engineering topic of general interest and relevance to the readership of the journal. The views expressed in this Forum article do not ...

ASCE-AMER SOC CIVIL ENGINEERS2019

Flavonoids are natural plant-derived compounds which have immense applications in pharmaceutical industry and have attracted the attention of both the industry and researchers involved in all fields of biology and medicine. Microbial production systems can ...

Wiley2019

Community-based landslide risk reduction: a review of a Red Cross soil bioengineering for resilience program in Honduras

Silvia Hostettler, Antonio D'Acunzi

Effective long-term participation of communities in disaster risk reduction measures in landslide-prone areas continues to be a challenge. This study aims to evaluate the extent to which community-based soil-bioengineering techniques allow for effective mi ...

2019

Lipids carry an important role in cell structure and function, as well as in the physiopathology of multiple diseases. Maintenance of the lipid profiles should be tightly regulated for preserving membrane permeability, cell integrity and several other func ...

2018