Publications related to Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

The transplantation of allogeneic islets in recent clinical trials has shown substantial promise as a therapy for type 1 diabetes; however, long-term insulin independence remains inadequate. This has been largely attributed to the current intravascular, he ...

Mary Ann Liebert, Inc2013

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

Matthias Lütolf, Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Adrian Ranga

By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...

National Academy of Sciences2013

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Michaël Unser, Daniel Sage, Christophe Bauer

Following on from the emerging importance of the pancreas circadian clock on islet function and the development of type 2 diabetes in rodent models, we aimed to examine circadian gene expression in human islets. The oscillator properties were assessed in i ...

Springer2013

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Witold Waldemar Kilarski, Marcin Stefan Zielinski

Therapeutic regulation of tissue vascularization has appeared as an attractive approach to treat a number of human diseases. In vivo neovascularization assays that reflect physiological and pathological formation of neovessels are important in this effort. ...

Springer Netherlands2012

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Chiara Greggio

The pancreas plays a central role in metabolism. The exocrine pancreas, composed of ductal and acinar cells, secretes and delivers digestive enzymes into the duodenum where they contribute to food digestion. The endocrine pancreas, constituted by the islet ...

EPFL2011

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

Mikaël Martino

Conducting tissue healing and regeneration through biomaterials and morphogens is still an unrealized goal. Understand the multiple roles of the extracellular matrix (ECM) is indeed essential for the design of successful regenerative medicine strategies. D ...

EPFL2011

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Jeffrey Alan Hubbell, Mikaël Martino, Federico Tortelli, Mayumi Mochizuki Martino

Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...

2011

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

Jeffrey Alan Hubbell, Mikaël Martino

It has recently been shown that some growth factors (GFs) have strong interactions with nonproteoglycan extracellular matrix proteins. Relevant here, the 12th-14th type three repeats of fibronectin (FN III12-14) have been shown to bind insulin-like growth ...

Federation of American Society of Experimental Biology2010

Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice

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Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Autonomous and self-sustained circadian oscillators displayed in human islet cells

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix