Transmembrane proteinA transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequently undergo significant conformational changes to move a substance through the membrane. They are usually highly hydrophobic and aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them (beta-barrels) can be also extracted using denaturing agents.
Blood transfusionBlood transfusion is the process of transferring blood products into a person's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern medical practice commonly uses only components of the blood, such as red blood cells, white blood cells, plasma, platelets, and other clotting factors. Red blood cells (RBC) contain hemoglobin, and supply the cells of the body with oxygen.
AnemiaAnemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen due to a lower than normal number of red blood cells, or a reduction in the amount of hemoglobin. The name is derived from ἀναιμία anaimia, meaning 'lack of blood', from ἀν- an-, 'not' and αἷμα haima, 'blood'. When anemia comes on slowly, the symptoms are often vague, such as tiredness, weakness, shortness of breath, headaches, and a reduced ability to exercise.
PentiumPentium is a series of x86 architecture-compatible microprocessors produced by Intel. The original Pentium was first released on March 22, 1993. Pentium-branded processors released from 2009 to 2022 are considered entry-level products that Intel rates as "two stars", meaning that they are above the low-end Atom and Celeron series, but below the faster Intel Core lineup and workstation/server Xeon series. These later Pentium processors have little more than their name in common with earlier Pentiums, which were Intel's flagship processor for over a decade until the introduction of the Intel Core line in 2006.
Coffee LakeCoffee Lake is Intel's codename for its eighth-generation Core microprocessor family, announced on September 25, 2017. It is manufactured using Intel's second 14 nm process node refinement. Desktop Coffee Lake processors introduced i5 and i7 CPUs featuring six cores (along with hyper-threading in the case of the latter) and Core i3 CPUs with four cores and no hyperthreading. On October 8, 2018, Intel announced what it branded its ninth generation of Core processors, the Coffee Lake Refresh family.
HemangiosarcomaHemangiosarcoma is a rapidly growing, highly invasive variety of cancer that occurs almost exclusively in dogs, and only rarely in cats, horses, mice, or humans (vinyl chloride toxicity). It is a sarcoma arising from the lining of blood vessels; that is, blood-filled channels and spaces are commonly observed microscopically. A frequent cause of death is the rupturing of this tumor, causing the patient to rapidly bleed to death. The term "angiosarcoma", when used without a modifier, usually refers to hemangiosarcoma.
HemoglobinopathyHemoglobinopathy is the medical term for a group of inherited blood disorders and diseases that primarily affect red blood cells. They are single-gene disorders and, in most cases, they are inherited as autosomal co-dominant traits. There are two main groups: abnormal structural hemoglobin variants caused by mutations in the hemoglobin genes, and the thalassemias, which are caused by an underproduction of otherwise normal hemoglobin molecules. The main structural hemoglobin variants are HbS, HbE and HbC.
