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Reconstruction and Simulation of Neocortical Microcircuitry

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Hand and face somatotopy shown using MRI-safe vibrotactile stimulation with a novel soft pneumatic actuator (SPA)-skin interface

Jamie Paik, Harshal Arun Sonar

The exact somatotopy of the human facial representation in the primary somatosensory cortex (S1) remains de-bated. One reason that progress has been hampered is due to the methodological challenge of how to apply automated vibrotactile stimuli to face area ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

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The vast majority of cortical synapses are found in the neuropil which is implicated in multiple and diverse functions underlying brain computation. Unraveling the organizing principles of the cortical neuropil requires an intricate characterization of syn ...

2022

In the neocortex, functionally distinct areas process specific types of information. Area identity is established by morphogens and transcriptional master regulators, but downstream mechanisms driving area-specific neuronal specification remain unclear. He ...

eLIFE SCIENCES PUBL LTD2022

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl

Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...

CELL PRESS2021

Creating a neuroprosthesis for active tactile exploration of textures

Solaiman Shokur, Miguel Nicolelis

Intracortical microstimulation (ICMS) of the primary somatosensory cortex (S1) can produce percepts that mimic somatic sensation and, thus, has potential as an approach to sensorize prosthetic limbs. However, it is not known whether ICMS could recreate act ...

2019

Layer, cell-type and pathway-specific thalamocortical input to mouse somatosensory cortex

Berat Semihcan Sermet

In the mouse whisker system, sensory information is relayed to the whisker somatosensory cortex by two major thalamic nuclei, the ventral posterior medial nucleus (VPM) and the posterior medial nucleus (POM). While the cortical axonal innervation pattern o ...

EPFL2018

Cardio-visual full body illusion alters bodily self-consciousness and tactile processing in somatosensory cortex

Olaf Blanke, Bruno Herbelin, Jane Aspell, Lukas Heydrich

Prominent theories highlight the importance of bodily perception for self-consciousness, but it is currently not known whether this is based on interoceptive or exteroceptive signals or on integrated signals from these anatomically distinct systems, nor wh ...

2018

Global efforts to create a molecular census of the brain using single-cell transcriptomics are producing a large catalog of molecularly defined cell types. However, spatial information is lacking and new methods are needed to map a large number of cell typ ...

2018

Parallel pathways from whisker and visual sensory cortices to distinct frontal regions of mouse neocortex

Carl Petersen, Varun Sreenivasan, Céline Matéo, Alexandros Kyriakatos

The spatial organization of mouse frontal cortex is poorly understood. Here, we used voltage-sensitive dye to image electrical activity in the dorsal cortex of awake head-restrained mice. Whisker-deflection evoked the earliest sensory response in a localiz ...

SPIE-Intl Soc Optical Eng2017

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Background: We present a visualization pipeline capable of accurate rendering of highly scattering fluorescent neocortical neuronal models. The pipeline is mainly developed to serve the computational neurobiology community. It allows the scientists to visu ...

2017