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Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

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Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

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Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors

Developing new tools to study and program cell fate at the single-cell level

Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation

High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres