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Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion

Related concepts (34)

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Human skin color

Human skin color ranges from the darkest brown to the lightest hues. Differences in skin color among individuals is caused by variation in pigmentation, which is the result of genetics (inherited from one's biological parents and or individual gene alleles), exposure to the sun, natural and sexual selection, or all of these. Differences across populations evolved through natural selection or sexual selection, because of social norms and differences in environment, as well as regulations of the biochemical effects of ultraviolet radiation penetrating the skin.

Basic fibroblast growth factor

Fibroblast growth factor 2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was first purified in 1975; soon thereafter three variants were isolated: 'basic FGF' (FGF2); Heparin-binding growth factor-2; and Endothelial cell growth factor-2.

Nintendo 64

The Nintendo 64 (N64) is a home video game console developed by Nintendo. It was released on June 23, 1996, in Japan; on September 26, 1996, in North America; and on March 1, 1997, in Europe and Australia. The successor to the Super Nintendo Entertainment System, it was the last major home console to use cartridges as its primary storage format until the Nintendo Switch in 2017. It competed primarily with the Sony PlayStation and the Sega Saturn.

IOS

iOS (formerly iPhone OS) is a mobile operating system developed by Apple Inc. exclusively for its hardware. It is the operating system that powers many of the company's mobile devices, including the iPhone; the term also includes the system software for iPads (predating iPadOS, which was introduced in 2019) as well as on the iPod Touch devices (which were discontinued in mid-2022). It is the world's second-most widely installed mobile operating system, after Android.