Development of portable prostate-specific membrane antigen (PSMA) ligands for targeted delivery applications and affinity maturation with DNA-encoded chemical libraries (DECLs)
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DNA-encoded chemical libraries (DECL) is a technology for the synthesis and screening on an unprecedented scale of collections of small molecule compounds. DECL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DECL technology is to accelerate the drug discovery process and in particular early phase discovery activities such as target validation and hit identification.