Diffuse correlation spectroscopy (DCS) is the technique of choice for non-invasive assessments of human bone blood flow. However, DCS classical algorithms are based on the fundamental assumption that the electric field of the light reaching the DCS photodetector is a zero-mean complex Gaussian variable. The non-validity of this hypothesis might produce inaccurate blood flow estimations. It is shown that for the human tibia, the "Gaussian hypothesis" holds for interoptode distances >= 20 mm. This lower boundary seems to depend on the type of investigated tissue. (C) 2016 Optical Society of America
Olivier Sauter, Laurent Villard, Stephan Brunner, Emmanuel Lanti, Alberto Bottino, Ben McMillan, Noé Thomas Elie Ohana