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Modulation of AMPK's activity via genetic tools and food-derived compounds as a novel approach to Parkinson's disease treatment
Related publications (33)
Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala
Maria del Carmen Sandi Perez, Hilal Lashuel, Johannes Burtscher, Jean-Christophe Copin
Increasing evidence suggests that crosstalk between α-synuclein pathology formation and mitochondrial dysfunction plays a central role in the pathogenesis of Parkinson’s disease and related synucleinopathies. While mitochondrial dysfunction is a well-studi ...
2020Multi-omics reveals abundant mitochondrial genomic and circadian expression variation in the Drosophila Genetic Reference Panel
Modern biology rapidly generates a wealth of data,which can only be analysed computationally.Despite the variety of available data types,most of them aim to provide an answer to one question: how does genotypic diversity translates into phenotypes? This qu ...
EPFL2020The phenotypic impact of naturally occurring genetic and molecular mitochondrial variation in a Drosophila Genetic Reference Population
Genome-wide association (GWA) studies aim to dissect the relationship between genotype and phenotype. So far, the focus has been on nuclear genetic determinants as variation in the mitochondrial genome is often low in the study cohorts. Despite this observ ...
EPFL2018Dopamine induces soluble alpha-synuclein oligomers and nigrostriatal degeneration
Parkinson's disease (PD) is defined by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy body inclusions containing aggregated alpha-synuclein. Efforts to explain dopamine neuron vulnerability are hindered by the lack of do ...
Nature Publishing Group2017Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease
Hilal Lashuel, Bohumil Maco, Abid Oueslati, Mohamed Bilal Fares
Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's disease (PD). Although doubling hα-Syn expression provokes LB pathology in ...
Natl Acad Sciences2016Advances in farm animal genomic resources
The history of livestock started with the domestication of their wild ancestors: a restricted number of species allowed to be tamed and entered a symbiotic relationship with humans. In exchange for food, shelter and protection, they provided us with meat, ...
Frontiers2016Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease
Athough it has been established for over 100 years that Lewy bodies (LBs) represent the major pathological hallmark of Parkinson's disease (PD), we still do not know why these fibrillar intra-neuronal inclusions of the α-Synuclein (α-Syn) protein form, and ...
EPFL2015Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis
Hilal Lashuel, Nadine Aït Bouziad, Anass Chiki, Ritwik Burai
Parkinsons disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of intraneuronal inclusions consisting of aggregated and post-translationally modified a-synuclein (a-syn). Despite advances in the chemic ...
Amer Chemical Soc2015Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle
Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Evan Graehl Williams, Norman Lionel Moullan, Hongbo Zhang, Eija Riitta Pirinen, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li
We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...
Elsevier2014Exploring the pathological interaction between LRRK2 and alpha-synuclein
Parkinson’s disease (PD) is the most common age-related neurodegenerative movement disorder that affects 1-2% of the general population over the age of 65 and rising to 4-5% over 80 years of age. It is estimated that 6.3 million people worldwide have Parki ...
EPFL2014