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Allosteric regulation and targeting of Abl SH2-kinase interface and other cytoplasmic tyrosine kinases

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Allosteric regulation and targeting of Abl SH2-kinase interface and other cytoplasmic tyrosine kinases

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Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and BCR-ABL1(T315I-E255K)

Allosteric regulation and targeting of Bruton's tyrosine kinase (Btk) in B-cell lymphoma

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

Precision Targeting of pten-Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing

Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1