Drug discoveryIn the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology.
Abelian varietyIn mathematics, particularly in algebraic geometry, complex analysis and algebraic number theory, an abelian variety is a projective algebraic variety that is also an algebraic group, i.e., has a group law that can be defined by regular functions. Abelian varieties are at the same time among the most studied objects in algebraic geometry and indispensable tools for much research on other topics in algebraic geometry and number theory. An abelian variety can be defined by equations having coefficients in any field; the variety is then said to be defined over that field.
Algebraic varietyAlgebraic varieties are the central objects of study in algebraic geometry, a sub-field of mathematics. Classically, an algebraic variety is defined as the set of solutions of a system of polynomial equations over the real or complex numbers. Modern definitions generalize this concept in several different ways, while attempting to preserve the geometric intuition behind the original definition. Conventions regarding the definition of an algebraic variety differ slightly.
IndoleIndole is an aromatic, heterocyclic, organic compound with the formula . It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. As an intercellular signal molecule, indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence.
CatalysisCatalysis (kəˈtæləsɪs) is the process of change in rate of a chemical reaction by adding a substance known as a catalyst (ˈkætəlɪst). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quickly, very small amounts of catalyst often suffice; mixing, surface area, and temperature are important factors in reaction rate. Catalysts generally react with one or more reactants to form intermediates that subsequently give the final reaction product, in the process of regenerating the catalyst.
Drug designDrug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it.
Rational varietyIn mathematics, a rational variety is an algebraic variety, over a given field K, which is birationally equivalent to a projective space of some dimension over K. This means that its function field is isomorphic to the field of all rational functions for some set of indeterminates, where d is the dimension of the variety. Let V be an affine algebraic variety of dimension d defined by a prime ideal I = ⟨f1, ..., fk⟩ in . If V is rational, then there are n + 1 polynomials g0, ..., gn in such that In order words, we have a of the variety.
Complete varietyIn mathematics, in particular in algebraic geometry, a complete algebraic variety is an algebraic variety X, such that for any variety Y the morphism is a closed map (i.e. maps closed sets onto closed sets). This can be seen as an analogue of compactness in algebraic geometry: a topological space X is compact if and only if the above projection map is closed with respect to topological products. The image of a complete variety is closed and is a complete variety. A closed subvariety of a complete variety is complete.
Indole alkaloidIndole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. Containing more than 4100 known different compounds, it is one of the largest classes of alkaloids. Many of them possess significant physiological activity and some of them are used in medicine. The amino acid tryptophan is the biochemical precursor of indole alkaloids. The action of some indole alkaloids has been known for ages.
Quasi-projective varietyIn mathematics, a quasi-projective variety in algebraic geometry is a locally closed subset of a projective variety, i.e., the intersection inside some projective space of a Zariski-open and a Zariski-closed subset. A similar definition is used in scheme theory, where a quasi-projective scheme is a locally closed subscheme of some projective space. An affine space is a Zariski-open subset of a projective space, and since any closed affine subset can be expressed as an intersection of the projective completion and the affine space embedded in the projective space, this implies that any affine variety is quasiprojective.
