Publication
Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis
Related publications (43)
Differential impact of TGF beta/SMAD signaling activity elicited by Activin A and Nodal on endoderm differentiation of epiblast stem cells
Allocation of cells to an endodermal fate in the gastrulating embryo is driven by Nodal signaling and consequent activation of TGF beta pathway. In vitro methodologies striving to recapitulate the process of endoderm differentiation, however, use TGF beta ...
WILEY2022Premature Vertebral Mineralization in hmx1-Mutant Zebrafish
H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development, and mutations in HMX1 are linked to an ocular defect termed oculoauricular syndrome of Schorderet-Munier-Franceschetti (OAS) (MIM #612109). Recently, additional altered oro ...
202290 YEARS OF PROGESTERONE Progesterone receptor signaling in the normal breast and its implications for cancer
Cathrin Brisken, Valentina Scabia
Progesterone is considered as the pregnancy hormone and acts on many different target tissues. Progesterone receptor (PR) signaling is important for normal development and the physiologic function of the breast and impinges on breast carcinogenesis. Both s ...
BIOSCIENTIFICA LTD2020Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle
Skeletal muscle holds significant regenerative potential but is incapable of restoring tissue loss caused by severe injury, congenital defects or tumour ablation. Consequently, skeletal muscle models are being developed to study human pathophysiology and r ...
WILEY2018Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila
Bruno Lemaitre, Jean Philippe Boquete, Jan Paul Dudzic, Sveta Chakrabarti, Xiaoxue Li, Esther Jeanne Collas
The JAK/STAT pathway is a key signaling pathway in the regulation of development and immunity in metazoans. In contrast to the multiple combinatorial JAK/STAT pathways in mammals, only one canonical JAK/STAT pathway exists in Drosophila. It is activated by ...
Public Library of Science2016The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma
Michel Aguet, Ivan Stamenkovic, Tanja Petricevic
Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS). Recent evidence suggests that deregulation of the Wnt pathway may play an important role in SS but the mechanisms whereby SS18-SSX might affect ...
Nature Publishing Group2016Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling
Christian Heinis, Pierre Vincent Dessen, Davide Bertoldo, Maola Khan Mohammad Golam
Upregulation of b-catenin, the primary mediator of the Wnt signaling pathway, plays an important role in the tumorigenesis of several types of human cancer. Targeting b-catenin to interfere with its ability to serve as a translational co-activator is consi ...
2016WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1
Glioblastoma is the most aggressive primary brain tumor in adults and due to the invasive nature cannot be completely removed. The WNT inhibitory factor 1 (WIF1), a secreted inhibitor of WNTs, is systematically downregulated in glioblastoma and acts as str ...
Nature Publishing Group2016CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer
Michel Aguet, Patrick Rodriguez, Mauro Delorenzi, Pascale Anderle Pedone, Andreas Eduard Moor, Norbert Wiedemann, Sylvie André Baflast, Frédérique Baruthio
BCL9/9L proteins enhance the transcriptional output of the beta-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9 ...
Elsevier Science Bv2015HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
Paloma Ordonez Moran, Caroline Dafflon
Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and identify ...
Elsevier2015