Publication
Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism
Related publications (68)
Circadian Rhythms and Mitochondria: Connecting the Dots
Carlos Canto Alvarez, Miriam Valera Alberni
Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evi ...
FRONTIERS MEDIA SA2018Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells
Cells live in ever-changing environments, thereby facing a variety of dynamic environmental signals. Environmental stimuli elicit intracellular responses through signaling pathways, which converge on transcriptional activation or repression of target genes ...
EPFL2018Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver
Circadian rhythms allow organisms to anticipate and adapt to periodic environmental changes related to the day-night cycle. These rhythms originate from a genetic network ticking in almost every cell of our body and the coordination between different organ ...
EPFL2018Rhythmic modulation of transcriptional burst frequency in circadian gene promoters
Isogenic cells sharing a common environment present a large degree of heterogeneity in gene expression, and stochasticity inherent to transcription substantially participates in this cell-to-cell variability. Notably, a majority of mammalian genes are tran ...
EPFL2017Rhythmic and clock-dependent chromatin loops regulate circadian gene expression
In mammals the circadian clock drives daily behavioural and physiological changes that resonate with environmental cues, which can be observed, for example, in the intricate timing of rest during the night and activity during the day in humans. The circadi ...
EPFL2017Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver
Felix Naef, Loïc Dayon, Frédéric Bruno Martin Gachon, Martin Kussmann, Daniel Alain Dominique Marie Mauvoisin, Jingkui Wang, Florian Atger, Federico Sizzano
Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulatio ...
Elsevier2017Tissue-specific enhancer repression through molecular integration of cell signaling inputs
Drosophila leg morphogenesis occurs under the control of a relatively well-known genetic cascade, which mobilizes both cell signaling pathways and tissue-specific transcription factors. However, their cross-regulatory interactions, deployed to refine leg p ...
2017Ribosome profiling and dynamic regulation of translation in mammals
Protein synthesis is an energy-demanding cellular process. Consequently, a well-timed, fine-tuned and plastic regulation of translation is needed to adjust and maintain cell states under dynamically changing environments. Genome-wide monitoring of translat ...
Elsevier2017Transforming Growth Factor beta/Activin signaling in neurons increases susceptibility to starvation
Bruno Lemaitre, Wen Bin Chng, Xiaoxue Li
Animals rely on complex signaling network to mobilize its energy stores during starvation. We have previously shown that the sugar-responsive TGF beta/Activin pathway, activated through the TGF beta ligand Dawdle, plays a central role in shaping the post-p ...
2017Phase specific transcriptional regulation of circadian clock and metabolism in mouse liver
The molecular clock has been conserved from cyanobacteria to mammals and is believed to align behavioral and biochemical processes with the diurnal cycle. This cellular mechanism has been an advantage to increase the fitness of organisms through the abilit ...
EPFL2016