Publication
In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons
Related publications (34)
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CELL PRESS2021Medium chain triglyceride diet reduces anxiety-like behaviors and enhances social competitiveness in rats
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Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. MCT are converted into ketones and free medium chain fatty acids that, in the brain, are highly effective ...
2018Unified multi-modal characterization of microstructural parameters of brain tissue using diffusion MRI and multi-echo T2 data
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In this study, a unified framework to estimate different microstructure indices from diffusion MRI and multi-echo T2 (MET2) data was proposed.The new methodology takes into account the common and complementary information provided by both modalities. While ...
2018Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies
Cristina Ramona Cudalbu, Veronika Rackayová
Creatine (Cr) is an important organic compound acting as intracellular high-energy phosphate shuttle and in energy storage. While located in most cells where it plays its main roles in energy metabolism and cytoprotection, Cr is highly concentrated in musc ...
Elsevier2017Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble
Pierre Magistretti, Igor Allaman, Jay Coggan, Renaud Jolivet
Glucose is the main energy substrate in the adult brain under normal conditions. Accumulating evidence, however, indicates that lactate produced in astrocytes (a type of glial cell) can also fuel neuronal activity. The quantitative aspects of this so-calle ...
Public Library of Science2015Brain energy metabolism measured by 13C magnetic resonance spectroscopy in vivo upon infusion of [3-13C]lactate
Rolf Gruetter, João Miguel das Neves Duarte, Freya-Merret Girault
The brain uses lactate produced by glycolysis as an energy source. How lactate originated from the blood stream is used to fuel brain metabolism is not clear. The current study measures brain metabolic fluxes and estimates the amount of pyruvate that becom ...
Wiley-Blackwell2015Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate
Pierre Magistretti, Jocelyne Bloch, Luc Pellerin
Lactate may represent a supplemental fuel for the brain. We examined cerebral lactate metabolism during prolonged brain glucose depletion (GD) in acute brain injury (ABI) patients monitored with cerebral microdialysis (CMD). Sixty episodes of GD (defined a ...
Mary Ann Liebert2015