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In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

Related publications (34)

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Simultaneous Chemical Recording and Stimulation in the Brain Using an Assembly of Biosensor Silicon Microprobes and SU-8 Microinjectors

Nico de Rooij, Peter Van der Wal, Olivier Frey

In this contribution we present multi-channel microinjector arrays fabricated by a reliable three-layer SU-8 process and assembled with glutamate biosensor microprobes1. It enables local delivery of specific liquids into brain tissue for the stimulation or ...

2009

Simultaneous Chemical Recording and Stimulation in the Brain Using an Assembly of Biosensor Silicon Microprobes and SU-8 Microinjectors

Nico de Rooij, Peter Van der Wal, Olivier Frey

In this contribution we present multi-channel microinjector arrays fabricated by a reliable three-layer SU-8 process and assembled with glutamate biosensor microprobes'. It enables local delivery of specific liquids into brain tissue for the stimulation or ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009

Astrocytes play a critical role in the regulation of brain metabolic responses to activity. One detailed mechanism proposed to describe the role of astrocytes in some of these responses has come to be known as the astrocyte-neuron lactate shuttle hypothesi ...

2007

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

Pierre Magistretti, Luc Pellerin

A critical issue in brain energy metabolism is whether lactate produced within the brain by astrocytes is taken up and metabolized by neurons upon activation. Although there is ample evidence that neurons can efficiently use lactate as an energy substrate, ...

2005

Glutamate was previously shown to enhance aerobic glycolysis i.e. increase glucose utilization and lactate production with no change in oxygen levels, in mouse cortical astrocytes by a mechanism involving glutamate uptake. It is reported here that a simila ...

2005

Neuroenergetics: calling upon astrocytes to satisfy hungry neurons

Pierre Magistretti, Luc Pellerin

Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a ...

2004

Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity

Rolf Gruetter

Glial cells are thought to supply energy for neurotransmission by increasing nonoxidative glycolysis; however, oxidative metabolism in glia may also contribute to increased brain activity. To study glial contribution to cerebral energy metabolism in the un ...

2004

The role of lactate in brain energy metabolism has recently received renewed attention. Although blood-borne monocarboxylates such as lactate poorly cross the blood-brain barrier in the adult brain, lactate produced within the brain parenchyma may be a sui ...

2000

Despite striking advances in functional brain imaging, the cellular and molecular mechanisms that underlie the signals detected by these techniques are still largely unknown. The basic physiological principle of functional imaging is represented by the tig ...

1999

Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain

Pierre Magistretti, Jean-Luc Martin, Luc Pellerin

Under particular circumstances like lactation and fasting, the blood-borne monocarboxylates acetoacetate, beta-hydroxybutyrate, and lactate represent significant energy substrates for the brain. Their utilization is dependent on a transport system present ...

1998