Publication
Use of VacA as a Vaccine Antigen
Related publications (53)
S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells
Cells have evolved endocytic pathways to internalize different molecules, to regulate intra-cellular communication and their interaction with external environment. Pathogens have co-evolved with cells to exploit these processes for infections. In particula ...
EPFL2024Interventionist estimands in event history analysis
The presence of competing events, such as death, makes it challenging to define causal effects on recurrent outcomes. In this thesis, I formalize causal inference for recurrent events, with and without competing events. I define several causal estimands an ...
EPFL2023Inhibitors of acyl protein thioesterases against microbial infections
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Valeria Cagno
The present invention relates inhibitors of acyl protein thioesterases and method of preparation thereof. It also relates to the use of inhibitors of acyl protein thioesterases in the treatment and/or prevention of a microbial infection such as viral or ba ...
2023Longevity of immunity following COVID-19 vaccination: a comprehensive review of the currently approved vaccines
It is unknown how long the immunity following COVID-19 vaccination lasts. The current systematic review provides a perspective on the persistence of various antibodies for available vaccines.Both the BNT162b2 and the mRNA-1273 induce the production of IgA ...
TAYLOR & FRANCIS INC2022Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder
Urinary tract infections (UTIs) are amongst the most common bacterial infections and are the second-most frequent reason for antibiotic prescriptions. Moreover, in about 25% of all treated cases, recurrence of infection occurs. Uropathogenic Escherichia co ...
EPFL2021Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine
Li Tang, Lixia Wei, Yu Zhao, Xiaomeng Hu
A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigen ...
2020Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity
Author summary Human cytomegalovirus (HCMV) infection is the foremost viral cause of congenital birth defects. Attempts to vaccinate against HCMV brought moderate, though not sufficient, reduction in infection. Moreover, phase II clinical trial with gB for ...
PUBLIC LIBRARY SCIENCE2020Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers
Marcela Rincón-Restrepo, Melody Swartz, Witold Waldemar Kilarski, Sachiko Hirosue, Alexandre de Titta, Esra Güç, David Scott Wilson
Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...
NATURE PUBLISHING GROUP2020Virus-Mediated Cell-Cell Fusion
Cell-cell fusion between eukaryotic cells is a general process involved in many physiological and pathological conditions, including infections by bacteria, parasites, and viruses. As obligate intracellular pathogens, viruses use intracellular machineries ...
2020Mammalian membrane trafficking as seen through the lens of bacterial toxins
Françoise Gisou van der Goot Grunberg, Francisco De Magalhães Sarmento R De Mesquita, Oksana Andrei Sergeeva
A fundamental question of eukaryotic cell biology is how membrane organelles are organised and interact with each other. Cell biologists address these questions by characterising the structural features of membrane compartments and the mechanisms that coor ...
WILEY2020