Publications related to Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Bidirectional motion of filaments: the role of motor proteins and passive cross linkers

In eukaryotic cells, motor proteins (MPs) bind to cytoskeletal filaments and move along them in a directed manner generating active stresses. During cell division a spindle structure of overlapping antiparallel microtubules forms whose stability and dynami ...

Royal Soc Chemistry2017

Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning

Pierre Gönczy, Coralie Busso, Benita Wolf

Zika virus (ZIKV) causes congenital microcephaly. Although ZIKV can impair cell cycle progression and provoke apoptosis, which probably contributes to disease aetiology through depletion of neural progenitor cells, additional cellular mechanisms may be imp ...

Royal Society, The2017

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Pierre Gönczy, Alessandro De Simone

The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...

Elsevier2016

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

Pierre Gönczy, Maria Josefina Marcaida Lopez, Sachin Kotak, Jean-Louis Reymond

Here we report the discovery of a selective inhibitor of Aurora A, a key regulator of cell division and potential anticancer target. We used the atom category extended ligand overlap score (xLOS), a 3D ligand-based virtual screening method recently develop ...

2016

The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding

Pierre Gönczy, Georgios Hatzopoulos, Paul Guichard

Centrioles are microtubule-based structures that play important roles notably in cell division and cilium biogenesis. CEP135/Bld10p family members are evolutionarily conserved microtubule-binding proteins important for centriole formation. Here, we analyze ...

Elsevier2016

Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN

Michaël Unser, Daniel Sage, Jacques Rougemont, Viesturs Simanis, Andrea Krapp, Daniel Andreas Schmitter, Anastasia Chasapi, Ioannis Xenarios

The Schizosaccharomyces pombe septation initiation network (SIN) regulates cytokinesis, and asymmetric association of SIN proteins with the mitotic spindle pole bodies (SPBs) is important for its regulation. Here, we have used semi-automated image analysis ...

Company Of Biologists Ltd2015

Pombe's thirteen - control of fission yeast cell division by the septation initiation network

Viesturs Simanis

The septation initiation network (SIN) regulates aspects of cell growth and division in Schizosaccharomyces pombe and is essential for cytokinesis. Insufficient signalling results in improper assembly of the contractile ring and failure of cytokinesis, gen ...

Company Of Biologists Ltd2015

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

Pierre Gönczy, Georgios Hatzopoulos, Nicola Jane Dynes, Sheng Kai Pong

Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic evol ...

2015

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos

Pierre Gönczy, Alessandro De Simone, Sylvain Träger, Kalyani Thyagarajan

Regulation of centrosome and spindle positioning is crucial for spatial cell division control. The one-cell Caenorhabditis elegans embryo has proven attractive for dissecting the mechanisms underlying centrosome and spindle positioning in a metazoan organi ...

Company Of Biologists Ltd2014

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Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Bidirectional motion of filaments: the role of motor proteins and passive cross linkers

Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning

Mechanisms of centrosome separation in C. elegans

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding

Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN

Pombe's thirteen - control of fission yeast cell division by the septation initiation network

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos

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Chat with Graph Search

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

Pombe's thirteen - control of fission yeast cell division by the septation initiation network

Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN

The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Mechanisms of centrosome separation in C. elegans

Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning

Bidirectional motion of filaments: the role of motor proteins and passive cross linkers

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos