Prefrontal cortexIn mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex. The PFC contains the Brodmann areas BA8, BA9, BA10, BA11, BA12, BA13, BA14, BA24, BA25, BA32, BA44, BA45, BA46, and BA47. The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals. Many authors have indicated an integral link between a person's will to live, personality, and the functions of the prefrontal cortex.
Brain mappingBrain mapping is a set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of the (human or non-human) brain resulting in maps. According to the definition established in 2013 by Society for Brain Mapping and Therapeutics (SBMT), brain mapping is specifically defined, in summary, as the study of the anatomy and function of the brain and spinal cord through the use of imaging, immunohistochemistry, molecular & optogenetics, stem cell and cellular biology, engineering, neurophysiology and nanotechnology.
Orders of magnitude (time)An order of magnitude of time is usually a decimal prefix or decimal order-of-magnitude quantity together with a base unit of time, like a microsecond or a million years. In some cases, the order of magnitude may be implied (usually 1), like a "second" or "year". In other cases, the quantity name implies the base unit, like "century". In most cases, the base unit is seconds or years. Prefixes are not usually used with a base unit of years. Therefore, it is said "a million years" instead of "a mega year".
Hubble Ultra-Deep FieldThe Hubble Ultra-Deep Field (HUDF) is a deep-field image of a small region of space in the constellation Fornax, containing an estimated 10,000 galaxies. The original data for the image was collected by the Hubble Space Telescope from September 2003 to January 2004. It includes light from galaxies that existed about 13 billion years ago, some 400 to 800 million years after the Big Bang. The HUDF image was taken in a section of the sky with a low density of bright stars in the near-field, allowing much better viewing of dimmer, more distant objects.
Anatomy of the cerebellumThe anatomy of the cerebellum can be viewed at three levels. At the level of gross anatomy, the cerebellum consists of a tightly folded and crumpled layer of cortex, with white matter underneath, several deep nuclei embedded in the white matter, and a fluid-filled ventricle in the middle. At the intermediate level, the cerebellum and its auxiliary structures can be broken down into several hundred or thousand independently functioning modules or compartments known as microzones.
Pathophysiology of multiple sclerosisMultiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage. The underlying cause is currently unknown. Current research in neuropathology, neuroimmunology, neurobiology, and neuroimaging, together with clinical neurology, provide support for the notion that MS is not a single disease but rather a spectrum.
Bundle metricIn differential geometry, the notion of a metric tensor can be extended to an arbitrary vector bundle, and to some principal fiber bundles. This metric is often called a bundle metric, or fibre metric. If M is a topological manifold and pi : E → M a vector bundle on M, then a metric on E is a bundle map k : E ×M E → M × R from the fiber product of E with itself to the trivial bundle with fiber R such that the restriction of k to each fibre over M is a nondegenerate bilinear map of vector spaces.
Tuberous sclerosisTuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin. A combination of symptoms may include seizures, intellectual disability, developmental delay, behavioral problems, skin abnormalities, lung disease, and kidney disease. TSC is caused by a mutation of either of two genes, TSC1 and TSC2, which code for the proteins hamartin and tuberin, respectively, with TSC2 mutations accounting for the majority and tending to cause more severe symptoms.
Associated Legendre polynomialsIn mathematics, the associated Legendre polynomials are the canonical solutions of the general Legendre equation or equivalently where the indices l and m (which are integers) are referred to as the degree and order of the associated Legendre polynomial respectively. This equation has nonzero solutions that are nonsingular on only if l and m are integers with 0 ≤ m ≤ l, or with trivially equivalent negative values. When in addition m is even, the function is a polynomial.
