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Eukaryotic transcription factor binding kinetics

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In vivo investigation of estrogenic activity by fluorescence techniques

Hanna Jankevics

Hormone binding nuclear receptors are transcription factors that activate gene transcription by binding to specific DNA sequences in the gene promoter region and then recruiting the necessary coactivator proteins for transcriptional activation. The knowled ...

EPFL2004

A global control region defines a chromosomal regulatory landscape containing the HoxD cluster

Denis Duboule

During limb development, coordinated expression of several Hoxd genes is required in presumptive digits. We searched for the underlying control sequences upstream from the cluster and found Lunapark (Lnp), a gene which shares limb and CNS expression specif ...

2003

Induced Protein Dimerization in Vivo through Covalent Labeling

Kai Johnsson

The authors present here a novel approach to induce protein dimerization in living cells through covalent labeling of fusion proteins with ligands which are interacting with other proteins. The covalent labeling is based on the reaction of the DNA repair p ...

2003

Regulation of the human telomerase reverse transcriptase gene

Joachim Lingner

Most somatic human cells lack telomerase activity because they do not express the telomerase reverse transcriptase (hTERT) gene. Conversely, most cancer cells express hTERT and are telomerase positive. For most tumors it is not clear whether hTERT expressi ...

2002

Chromosome dynamics in the yeast interphase nucleus

Thierry Laroche

Little is known about the dynamics of chromosomes in interphase nuclei. By tagging four chromosomal regions with a green fluorescent protein fusion to lac repressor, we monitored the movement and subnuclear position of specific sites in the yeast genome, s ...

2001

Transcriptional control of adipogenesis

Johan Auwerx

Adipocyte differentiation is coordinatedly regulated by several transcription factors. C/EBP beta, C/EBP delta and ADD-1/SREBP-1 are active early during the differentiation process and induce the expression and/or activity of the peroxisome proliferator ac ...

1998

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

Thierry Laroche

The mammalian Ku70 and Ku86 proteins form a heterodimer that binds to the ends of double-stranded DNA in vitro and is required for repair of radiation-induced strand breaks and V(D)J recombination [1,2]. Deletion of the Saccharomyces cerevisiae genes HDF1 ...

1998

Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1.

John McKinney

The transcripts of many genes involved in Saccharomyces cerevisiae mating were found to fluctuate during the cell cycle. In the absence of a functional Ste12 transcription factor, both the levels and the cell cycle pattern of expression of these genes were ...

1996

Functional domains of the heavy metal-responsive transcription regulator MTF-1

Freddy Radtke

Metallothioneins (MTs) constitute a class of low molecular weight, cysteine-rich, metal binding proteins which are regulated at the level of gene transcription in response to heavy metals and other adverse treatments. We have previously cloned a zinc finge ...

1995

Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element

Philipp Bucher

We have biochemically and functionally characterized a new transcription factor, NP-TCII, which is present in nuclei from unstimulated T and B lymphocytes but is not found in nonhematopoietic cells. This factor has a DNA-binding specificity similar to that ...

1992