Miniaturized Dielectric Elastomer Actuator for Mechanical Stimulation of Monolayer Cell Cultures
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The aim of the present thesis is to provide a numerical tool for the mechanical modeling of dynamic failure in concrete. This widely used construction material is characterized by a non-linear failure behavior, which is consequently difficult to describe w ...
A split Hopkinson pressure bar system with a special shape striker has been suggested as the test method by the International Society for Rock Mechanics (ISRM) to determine the dynamic characteristics of rock materials. In order to further verify this test ...
To study the deformation and fracture of sandstone under static-dynamic coupled load, a cylindrical specimen under pre-static axial and confining pressure was dynamically loaded using an improved split Hopkinson pressure bar (SHPB). Through the application ...
The impedance of biological material changes with frequency, a phenomenon that has been discovered more than 100 years ago. It is due to the fact that the cell membrane acts as a capacitor which filters out currents at low frequency and lets them pass at h ...
EPFL2013
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We present an array of micro artificial muscles developed for investigation of cells response to mechanical strain. Few technologies can be used to realise this type of study. However, in most cases a compromise is required and one must choose between high ...
2013
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Fluorescent nanosensor probes have suffered from limited mol. recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathol ...
2014
In various single-molecule experiments, a chiral polymer, such as DNA, is simultaneously pulled and twisted. We address an elementary but fundamental question raised by various authors: does the molecule overwind or unwind under tension? We show that withi ...
Digital image correlation (DIC) is assessed as a tool for measuring strains with high spatial resolution in woven-fiber ceramic matrix composites. Using results of mechanical tests on aluminum alloy specimens in various geometric configurations, guidelines ...
Biological cells modulate their behavior, express genes, proliferate or differentiate in response to mechanical strains ranging from 1% to 20%. There currently exists no technique to apply strain to many targeted individual cells in a larger culture in ord ...
Cells regulate their behavior in response to mechanical strains. Cell cultures to study mechanotransuction are typically cm2 in area, far too large to monitor single cell response. We have developed an array of dielectric elastomer microactuators as a tool ...
