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Novel Instrumentation and Methods for Chemical Applications of Dissolution Dynamic Nuclear Polarization
Related publications (86)
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Nuclear magnetic resonance (NMR) methods are powerful tools employed in many fields, including physics, chemistry, material science, biology, and medicine. The use of NMR methodologies in an even wider range of applications is often hindered by the relativ ...
EPFL2023H-1 Hyperpolarization of Solutions by Overhauser Dynamic Nuclear Polarization with C-13-H-1 Polarization Transfer
David Lyndon Emsley, Yu Rao, Pinelopi Moutzouri, Amrit Venkatesh
Dynamic nuclear polarization (DNP) is a method that can significantly increase the sensitivity of nuclear magnetic resonance. The only effective DNP mechanism for in situ hyperpolarization in solution is Overhauser DNP, which is inefficient for H-1 at high ...
AMER CHEMICAL SOC2022Dnp biosensor
Jean-Philippe Ansermet, Jonas Milani
Method for detecting a change in molecular tumbling of an electron-spin labelled system (1) in solution. Nuclear spins of the entire solution are measured in solution using Overhauser dynamic nuclear polarization in a first reference measurement, and then ...
2022Performance and reproducibility of C-13 and N-15 hyperpolarization using a cryogen-free DNP polarizer
Hikari Ananda Infinity Yoshihara, Arianna Ferrari
The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using ...
NATURE PORTFOLIO2022Method for the preparation of a sample comprising highly polarized nuclear spins and uses and devices for such a method
Jean-Philippe Ansermet, Christophe Roussel, Jonas Milani
Method for the preparation of a sample comprising highly polarized nuclear spins, comprising at least the following steps: a) bringing a polarization system, which using an electrochemical reaction can be converted into an EPR-active radical form thereof, ...
2021Direct measurement of the triple spin flip rate in dynamic nuclear polarization
A previous study of the effect of Gadolinium doping on the dynamic polarization (DNP) of C-13 using trityls showed that the rate at which the polarization builds up is almost independent of the Gadolinium concentration, while the electron spin-lattice rela ...
2021TinyPols: a family of water-soluble binitroxides tailored for dynamic nuclear polarization enhanced NMR spectroscopy at 18.8 and 21.1 T
David Lyndon Emsley, Moreno Lelli, Gabriele Stevanato, Georges Guévork Jean-Jacques Menzildjian, David Benjamin Roger Antoine Gajan
Dynamic Nuclear Polarization (DNP) has recently emerged as a key method to increase the sensitivity of solid-state NMR spectroscopy under Magic Angle Spinning (MAS). While efficient binitroxide polarizing agents such as AMUPol have been developed for MAS D ...
ROYAL SOC CHEMISTRY2020Enhanced Intersystem Crossing and Transient Electron Spin Polarization in a Photoexcited Pentacene–Trityl Radical
David Lyndon Emsley, Jacques-Edouard Moser, Aaron James Rossini, Dominik Józef Kubicki, Moreno Lelli, Etienne Christophe Socie, Gabriele Stevanato, Claudia Esther Avalos
Identifying and characterizing systems that generate well-defined states with large electron spin polarization is of high interest for applications in molecular spintronics, high-energy physics, and magnetic resonance spectroscopy. The generation of electr ...
2020Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances
Andrea Capozzi, Arthur César Pinon
Dissolution-DNP is a method to boost liquid-state NMR sensitivity by several orders of magnitude. The technique consists in hyperpolarizing samples by solid-state dynamic nuclear polarization at low temperature and moderate magnetic field, followed by an i ...
SPRINGER2020Maximizing nuclear hyperpolarization in pulse cooling under MAS
David Lyndon Emsley, Brennan James Walder, Nicolas Luc Matthey
It has recently been shown how dynamic nuclear polarization can be used to hyperpolarize the bulk of proton-free solids. This is achieved by generating the polarization in a wetting phase, transferring it to nuclei near the surface and relaying it towards ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2019